A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study

RN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synthesiz...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Deqin, Yao, Yanli, Tang, Yubo, Wang, Zheng, Shi, Wei, Huang, Wei, Ding, Kan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418633/
https://www.ncbi.nlm.nih.gov/pubmed/30965840
http://dx.doi.org/10.3390/polym9100536
_version_ 1783403775061393408
author Cai, Deqin
Yao, Yanli
Tang, Yubo
Wang, Zheng
Shi, Wei
Huang, Wei
Ding, Kan
author_facet Cai, Deqin
Yao, Yanli
Tang, Yubo
Wang, Zheng
Shi, Wei
Huang, Wei
Ding, Kan
author_sort Cai, Deqin
collection PubMed
description RN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synthesized via [3+2] or [2+2] strategies, efficiently. Two pentasaccharides, 18 and 27, showed similar inhibition effect on pancreatic cancer BxPC-3 cells to that of RN1 at same concentration. Interestingly, tetrasaccharide 21 potently inhibited gemcitabineresistant cell line Panc-1 at high concentration. These suggest that the branches of RN1 might be the active targeting domain and tetrasaccharide 21 might be a potential leading compound for pancreatic cancer with gemcitabine resistance.
format Online
Article
Text
id pubmed-6418633
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64186332019-04-02 A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study Cai, Deqin Yao, Yanli Tang, Yubo Wang, Zheng Shi, Wei Huang, Wei Ding, Kan Polymers (Basel) Article RN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synthesized via [3+2] or [2+2] strategies, efficiently. Two pentasaccharides, 18 and 27, showed similar inhibition effect on pancreatic cancer BxPC-3 cells to that of RN1 at same concentration. Interestingly, tetrasaccharide 21 potently inhibited gemcitabineresistant cell line Panc-1 at high concentration. These suggest that the branches of RN1 might be the active targeting domain and tetrasaccharide 21 might be a potential leading compound for pancreatic cancer with gemcitabine resistance. MDPI 2017-10-21 /pmc/articles/PMC6418633/ /pubmed/30965840 http://dx.doi.org/10.3390/polym9100536 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cai, Deqin
Yao, Yanli
Tang, Yubo
Wang, Zheng
Shi, Wei
Huang, Wei
Ding, Kan
A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_full A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_fullStr A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_full_unstemmed A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_short A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_sort concise synthesis of three branches derived from polysaccharide rn1 and anti-pancreatic cancer activity study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418633/
https://www.ncbi.nlm.nih.gov/pubmed/30965840
http://dx.doi.org/10.3390/polym9100536
work_keys_str_mv AT caideqin aconcisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT yaoyanli aconcisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT tangyubo aconcisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT wangzheng aconcisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT shiwei aconcisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT huangwei aconcisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT dingkan aconcisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT caideqin concisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT yaoyanli concisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT tangyubo concisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT wangzheng concisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT shiwei concisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT huangwei concisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy
AT dingkan concisesynthesisofthreebranchesderivedfrompolysaccharidern1andantipancreaticcanceractivitystudy

Ejemplares similares