Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

We here present the synthesis and characterization of a set of biodegradable core–multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18, 19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ethe...

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Autores principales: Unbehauen, Michael L., Fleige, Emanuel, Paulus, Florian, Schemmer, Brigitta, Mecking, Stefan, Moré, Sam Dylan, Haag, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418772/
https://www.ncbi.nlm.nih.gov/pubmed/30970993
http://dx.doi.org/10.3390/polym9080316
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author Unbehauen, Michael L.
Fleige, Emanuel
Paulus, Florian
Schemmer, Brigitta
Mecking, Stefan
Moré, Sam Dylan
Haag, Rainer
author_facet Unbehauen, Michael L.
Fleige, Emanuel
Paulus, Florian
Schemmer, Brigitta
Mecking, Stefan
Moré, Sam Dylan
Haag, Rainer
author_sort Unbehauen, Michael L.
collection PubMed
description We here present the synthesis and characterization of a set of biodegradable core–multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18, 19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery.
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spelling pubmed-64187722019-04-02 Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus Unbehauen, Michael L. Fleige, Emanuel Paulus, Florian Schemmer, Brigitta Mecking, Stefan Moré, Sam Dylan Haag, Rainer Polymers (Basel) Article We here present the synthesis and characterization of a set of biodegradable core–multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18, 19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery. MDPI 2017-07-29 /pmc/articles/PMC6418772/ /pubmed/30970993 http://dx.doi.org/10.3390/polym9080316 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Unbehauen, Michael L.
Fleige, Emanuel
Paulus, Florian
Schemmer, Brigitta
Mecking, Stefan
Moré, Sam Dylan
Haag, Rainer
Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus
title Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus
title_full Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus
title_fullStr Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus
title_full_unstemmed Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus
title_short Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus
title_sort biodegradable core–multishell nanocarriers: influence of inner shell structure on the encapsulation behavior of dexamethasone and tacrolimus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418772/
https://www.ncbi.nlm.nih.gov/pubmed/30970993
http://dx.doi.org/10.3390/polym9080316
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