Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing

Cinnamaldehyde (CA) was successfully encapsulated in β-cyclodextrin (β-CD), and polylactic acid (PLA)-based composite fibers were prepared by incorporating CA/β-CD via electrospinning. Morphological, structural, spectral, and antibacterial properties of different weight ratios of PLA:β-CD/CA (88:12,...

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Detalles Bibliográficos
Autores principales: Liu, Yaowen, Liang, Xue, Zhang, Rong, Lan, Wenting, Qin, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418790/
https://www.ncbi.nlm.nih.gov/pubmed/30965767
http://dx.doi.org/10.3390/polym9100464
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author Liu, Yaowen
Liang, Xue
Zhang, Rong
Lan, Wenting
Qin, Wen
author_facet Liu, Yaowen
Liang, Xue
Zhang, Rong
Lan, Wenting
Qin, Wen
author_sort Liu, Yaowen
collection PubMed
description Cinnamaldehyde (CA) was successfully encapsulated in β-cyclodextrin (β-CD), and polylactic acid (PLA)-based composite fibers were prepared by incorporating CA/β-CD via electrospinning. Morphological, structural, spectral, and antibacterial properties of different weight ratios of PLA:β-CD/CA (88:12, 94:6, 97:3, and 98.5:1.5) and PLA/CA/β-CD fibers were investigated. PLA and CA/β-CD were incorporated by mixing of CA/β-CD inclusions to enhance the viscosity of the mixed solution. The mechanical properties and hydrophilicity of nanofibers were improved following the addition of CA/β-CD. Moreover, CA/β-CD improved the antibacterial activities of the mixture against Escherichia coli and Staphylococcus aureus. PLA/CA/β-CD-3 exhibited excellent antibacterial effects and low cytotoxicity. Thus, our study showed that PLA/CA/β-CD fibers may have applications as wound dressing materials and for use in other biomedical applications.
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spelling pubmed-64187902019-04-02 Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing Liu, Yaowen Liang, Xue Zhang, Rong Lan, Wenting Qin, Wen Polymers (Basel) Article Cinnamaldehyde (CA) was successfully encapsulated in β-cyclodextrin (β-CD), and polylactic acid (PLA)-based composite fibers were prepared by incorporating CA/β-CD via electrospinning. Morphological, structural, spectral, and antibacterial properties of different weight ratios of PLA:β-CD/CA (88:12, 94:6, 97:3, and 98.5:1.5) and PLA/CA/β-CD fibers were investigated. PLA and CA/β-CD were incorporated by mixing of CA/β-CD inclusions to enhance the viscosity of the mixed solution. The mechanical properties and hydrophilicity of nanofibers were improved following the addition of CA/β-CD. Moreover, CA/β-CD improved the antibacterial activities of the mixture against Escherichia coli and Staphylococcus aureus. PLA/CA/β-CD-3 exhibited excellent antibacterial effects and low cytotoxicity. Thus, our study showed that PLA/CA/β-CD fibers may have applications as wound dressing materials and for use in other biomedical applications. MDPI 2017-09-21 /pmc/articles/PMC6418790/ /pubmed/30965767 http://dx.doi.org/10.3390/polym9100464 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Yaowen
Liang, Xue
Zhang, Rong
Lan, Wenting
Qin, Wen
Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing
title Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing
title_full Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing
title_fullStr Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing
title_full_unstemmed Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing
title_short Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing
title_sort fabrication of electrospun polylactic acid/cinnamaldehyde/β-cyclodextrin fibers as an antimicrobial wound dressing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418790/
https://www.ncbi.nlm.nih.gov/pubmed/30965767
http://dx.doi.org/10.3390/polym9100464
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