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Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation

Here, we report the synthesis of new thermoresponsive hyperbranched polymers (HBPs) via one-pot reversible addition-fragmentation chain transfer (RAFT) copolymerisation of poly(ethylene glycol)methyl ether methacrylate (PEGMEMA, M(n) = 475 g/mol), poly(propylene glycol)methacrylate (PPGMA, M(n) = 37...

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Autores principales: Tochwin, Anna, El-Betany, Alaa, Tai, Hongyun, Chan, Kai Yu, Blackburn, Chester, Wang, Wenxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418797/
https://www.ncbi.nlm.nih.gov/pubmed/30965746
http://dx.doi.org/10.3390/polym9090443
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author Tochwin, Anna
El-Betany, Alaa
Tai, Hongyun
Chan, Kai Yu
Blackburn, Chester
Wang, Wenxin
author_facet Tochwin, Anna
El-Betany, Alaa
Tai, Hongyun
Chan, Kai Yu
Blackburn, Chester
Wang, Wenxin
author_sort Tochwin, Anna
collection PubMed
description Here, we report the synthesis of new thermoresponsive hyperbranched polymers (HBPs) via one-pot reversible addition-fragmentation chain transfer (RAFT) copolymerisation of poly(ethylene glycol)methyl ether methacrylate (PEGMEMA, M(n) = 475 g/mol), poly(propylene glycol)methacrylate (PPGMA, M(n) = 375 g/mol), and disulfide diacrylate (DSDA) using 2-cyanoprop-2-yl dithiobenzoate as a RAFT agent. DSDA was used as the branching agent and to afford the HBPs with reducible disulfide groups. The resulting HBPs were characterised by Nuclear Magnetic Resonance Spectroscopy (NMR) and Gel Permeation Chromatography (GPC). Differential Scanning Calorimetry (DSC) was used to determine lower critical solution temperatures (LCSTs) of these copolymers, which are in the range of 17–57 °C. Moreover, the studies on the reducibility of HBPs and swelling behaviours of hydrogels synthesized from these HBPs were conducted. The results demonstrated that we have successfully synthesized hyperbranched polymers with desired dual responsive (thermal and reducible) and crosslinkable (via thiol-ene click chemistry) properties. In addition, these new HBPs carry the multiplicity of reactive functionalities, such as RAFT agent moieties and multivinyl functional groups, which can afford them with the capacity for further bioconjugation and structure modifications.
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spelling pubmed-64187972019-04-02 Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation Tochwin, Anna El-Betany, Alaa Tai, Hongyun Chan, Kai Yu Blackburn, Chester Wang, Wenxin Polymers (Basel) Article Here, we report the synthesis of new thermoresponsive hyperbranched polymers (HBPs) via one-pot reversible addition-fragmentation chain transfer (RAFT) copolymerisation of poly(ethylene glycol)methyl ether methacrylate (PEGMEMA, M(n) = 475 g/mol), poly(propylene glycol)methacrylate (PPGMA, M(n) = 375 g/mol), and disulfide diacrylate (DSDA) using 2-cyanoprop-2-yl dithiobenzoate as a RAFT agent. DSDA was used as the branching agent and to afford the HBPs with reducible disulfide groups. The resulting HBPs were characterised by Nuclear Magnetic Resonance Spectroscopy (NMR) and Gel Permeation Chromatography (GPC). Differential Scanning Calorimetry (DSC) was used to determine lower critical solution temperatures (LCSTs) of these copolymers, which are in the range of 17–57 °C. Moreover, the studies on the reducibility of HBPs and swelling behaviours of hydrogels synthesized from these HBPs were conducted. The results demonstrated that we have successfully synthesized hyperbranched polymers with desired dual responsive (thermal and reducible) and crosslinkable (via thiol-ene click chemistry) properties. In addition, these new HBPs carry the multiplicity of reactive functionalities, such as RAFT agent moieties and multivinyl functional groups, which can afford them with the capacity for further bioconjugation and structure modifications. MDPI 2017-09-13 /pmc/articles/PMC6418797/ /pubmed/30965746 http://dx.doi.org/10.3390/polym9090443 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tochwin, Anna
El-Betany, Alaa
Tai, Hongyun
Chan, Kai Yu
Blackburn, Chester
Wang, Wenxin
Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation
title Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation
title_full Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation
title_fullStr Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation
title_full_unstemmed Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation
title_short Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation
title_sort thermoresponsive and reducible hyperbranched polymers synthesized by raft polymerisation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418797/
https://www.ncbi.nlm.nih.gov/pubmed/30965746
http://dx.doi.org/10.3390/polym9090443
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