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Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils

Alginate and cellulose nanofibrils (CNF) are attractive materials for tissue engineering and regenerative medicine. CNF gels are generally weaker and more brittle than alginate gels, while alginate gels are elastic and have high rupture strength. Alginate properties depend on their guluronan and man...

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Autores principales: Aarstad, Olav, Heggset, Ellinor Bævre, Pedersen, Ina Sander, Bjørnøy, Sindre Hove, Syverud, Kristin, Strand, Berit Løkensgard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418825/
https://www.ncbi.nlm.nih.gov/pubmed/30971055
http://dx.doi.org/10.3390/polym9080378
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author Aarstad, Olav
Heggset, Ellinor Bævre
Pedersen, Ina Sander
Bjørnøy, Sindre Hove
Syverud, Kristin
Strand, Berit Løkensgard
author_facet Aarstad, Olav
Heggset, Ellinor Bævre
Pedersen, Ina Sander
Bjørnøy, Sindre Hove
Syverud, Kristin
Strand, Berit Løkensgard
author_sort Aarstad, Olav
collection PubMed
description Alginate and cellulose nanofibrils (CNF) are attractive materials for tissue engineering and regenerative medicine. CNF gels are generally weaker and more brittle than alginate gels, while alginate gels are elastic and have high rupture strength. Alginate properties depend on their guluronan and mannuronan content and their sequence pattern and molecular weight. Likewise, CNF exists in various qualities with properties depending on, e.g., morphology and charge density. In this study combinations of three types of alginate with different composition and two types of CNF with different charge and degree of fibrillation have been studied. Assessments of the composite gels revealed that attractive properties like high rupture strength, high compressibility, high gel rigidity at small deformations (Young’s modulus), and low syneresis was obtained compared to the pure gels. The effects varied with relative amounts of CNF and alginate, alginate type, and CNF quality. The largest effects were obtained by combining oxidized CNF with the alginates. Hence, by combining the two biopolymers in composite gels, it is possible to tune the rupture strength, Young’s modulus, syneresis, as well as stability in physiological saline solution, which are all important properties for the use as scaffolds in tissue engineering.
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spelling pubmed-64188252019-04-02 Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils Aarstad, Olav Heggset, Ellinor Bævre Pedersen, Ina Sander Bjørnøy, Sindre Hove Syverud, Kristin Strand, Berit Løkensgard Polymers (Basel) Article Alginate and cellulose nanofibrils (CNF) are attractive materials for tissue engineering and regenerative medicine. CNF gels are generally weaker and more brittle than alginate gels, while alginate gels are elastic and have high rupture strength. Alginate properties depend on their guluronan and mannuronan content and their sequence pattern and molecular weight. Likewise, CNF exists in various qualities with properties depending on, e.g., morphology and charge density. In this study combinations of three types of alginate with different composition and two types of CNF with different charge and degree of fibrillation have been studied. Assessments of the composite gels revealed that attractive properties like high rupture strength, high compressibility, high gel rigidity at small deformations (Young’s modulus), and low syneresis was obtained compared to the pure gels. The effects varied with relative amounts of CNF and alginate, alginate type, and CNF quality. The largest effects were obtained by combining oxidized CNF with the alginates. Hence, by combining the two biopolymers in composite gels, it is possible to tune the rupture strength, Young’s modulus, syneresis, as well as stability in physiological saline solution, which are all important properties for the use as scaffolds in tissue engineering. MDPI 2017-08-19 /pmc/articles/PMC6418825/ /pubmed/30971055 http://dx.doi.org/10.3390/polym9080378 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aarstad, Olav
Heggset, Ellinor Bævre
Pedersen, Ina Sander
Bjørnøy, Sindre Hove
Syverud, Kristin
Strand, Berit Løkensgard
Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils
title Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils
title_full Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils
title_fullStr Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils
title_full_unstemmed Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils
title_short Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils
title_sort mechanical properties of composite hydrogels of alginate and cellulose nanofibrils
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418825/
https://www.ncbi.nlm.nih.gov/pubmed/30971055
http://dx.doi.org/10.3390/polym9080378
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