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Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform
The implementation of Molecularly Imprinted Polymers (MIPs) into sensing systems has been demonstrated abundantly over the past few decades. In this article, a novel application for an MIP-based thermal sensing platform is introduced by using the sensor to characterize the drug release kinetics of a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418916/ https://www.ncbi.nlm.nih.gov/pubmed/30965864 http://dx.doi.org/10.3390/polym9110560 |
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author | Pawley, Christopher J. Perez-Gavilan, Ariane Foley, Kaelin S. Lentink, Sarah Welsh, Hannah N. Tuijthof, Gabrielle Steen Redeker, Erik Diliën, Hanne Eersels, Kasper van Grinsven, Bart Cleij, Thomas J. |
author_facet | Pawley, Christopher J. Perez-Gavilan, Ariane Foley, Kaelin S. Lentink, Sarah Welsh, Hannah N. Tuijthof, Gabrielle Steen Redeker, Erik Diliën, Hanne Eersels, Kasper van Grinsven, Bart Cleij, Thomas J. |
author_sort | Pawley, Christopher J. |
collection | PubMed |
description | The implementation of Molecularly Imprinted Polymers (MIPs) into sensing systems has been demonstrated abundantly over the past few decades. In this article, a novel application for an MIP-based thermal sensing platform is introduced by using the sensor to characterize the drug release kinetics of a nanoporous silver-organic framework. This Ag nanoporous matrix was loaded with acetylsalicylic acid (aspirin) which was used as a model drug compound in this study. The drug elution properties were studied by placing the nanoporous matrix in phosphate buffered saline solution for two days and measuring the drug concentration at regular time intervals. To this extent, an acrylamide-based MIP was synthesized that was able to detect aspirin in a specific and selective manner. Rebinding of the template to the MIP was analyzed using a thermal sensor platform. The results illustrate that the addition of aspirin into the sensing chamber leads to a concentration-dependent increase in the phase shift of a thermal wave that propagates through the MIP-coated sensor chip. After constructing a dose-response curve, this system was used to study the drug release kinetics of the nanoporous matrix, clearly demonstrating that the metalorganic framework releases the drug steadily over the course of the first hour, after which the concentration reaches a plateau. These findings were further confirmed by UV–Visible spectroscopy, illustrating a similar time-dependent release in the same concentration range, which demonstrates that the MIP-based platform can indeed be used as a low-cost straightforward tool to assess the efficacy of drug delivery systems in a lab environment. |
format | Online Article Text |
id | pubmed-6418916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64189162019-04-02 Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform Pawley, Christopher J. Perez-Gavilan, Ariane Foley, Kaelin S. Lentink, Sarah Welsh, Hannah N. Tuijthof, Gabrielle Steen Redeker, Erik Diliën, Hanne Eersels, Kasper van Grinsven, Bart Cleij, Thomas J. Polymers (Basel) Article The implementation of Molecularly Imprinted Polymers (MIPs) into sensing systems has been demonstrated abundantly over the past few decades. In this article, a novel application for an MIP-based thermal sensing platform is introduced by using the sensor to characterize the drug release kinetics of a nanoporous silver-organic framework. This Ag nanoporous matrix was loaded with acetylsalicylic acid (aspirin) which was used as a model drug compound in this study. The drug elution properties were studied by placing the nanoporous matrix in phosphate buffered saline solution for two days and measuring the drug concentration at regular time intervals. To this extent, an acrylamide-based MIP was synthesized that was able to detect aspirin in a specific and selective manner. Rebinding of the template to the MIP was analyzed using a thermal sensor platform. The results illustrate that the addition of aspirin into the sensing chamber leads to a concentration-dependent increase in the phase shift of a thermal wave that propagates through the MIP-coated sensor chip. After constructing a dose-response curve, this system was used to study the drug release kinetics of the nanoporous matrix, clearly demonstrating that the metalorganic framework releases the drug steadily over the course of the first hour, after which the concentration reaches a plateau. These findings were further confirmed by UV–Visible spectroscopy, illustrating a similar time-dependent release in the same concentration range, which demonstrates that the MIP-based platform can indeed be used as a low-cost straightforward tool to assess the efficacy of drug delivery systems in a lab environment. MDPI 2017-10-28 /pmc/articles/PMC6418916/ /pubmed/30965864 http://dx.doi.org/10.3390/polym9110560 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pawley, Christopher J. Perez-Gavilan, Ariane Foley, Kaelin S. Lentink, Sarah Welsh, Hannah N. Tuijthof, Gabrielle Steen Redeker, Erik Diliën, Hanne Eersels, Kasper van Grinsven, Bart Cleij, Thomas J. Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform |
title | Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform |
title_full | Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform |
title_fullStr | Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform |
title_full_unstemmed | Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform |
title_short | Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform |
title_sort | studying the drug delivery kinetics of a nanoporous matrix using a mip-based thermal sensing platform |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418916/ https://www.ncbi.nlm.nih.gov/pubmed/30965864 http://dx.doi.org/10.3390/polym9110560 |
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