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Supercritical Assisted Electrospray: An Improved Micronization Process

A new process is proposed that can largely improve classical electrospray (ESPR) atomization, thanks to the addition of supercritical CO(2) (SC-CO(2)) to the liquid mixture, in which a polymer is dissolved, forming an expanded liquid. The consequent reduction of surface tension and viscosity allows...

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Detalles Bibliográficos
Autores principales: Baldino, Lucia, Cardea, Stefano, Reverchon, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419022/
https://www.ncbi.nlm.nih.gov/pubmed/30960228
http://dx.doi.org/10.3390/polym11020244
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author Baldino, Lucia
Cardea, Stefano
Reverchon, Ernesto
author_facet Baldino, Lucia
Cardea, Stefano
Reverchon, Ernesto
author_sort Baldino, Lucia
collection PubMed
description A new process is proposed that can largely improve classical electrospray (ESPR) atomization, thanks to the addition of supercritical CO(2) (SC-CO(2)) to the liquid mixture, in which a polymer is dissolved, forming an expanded liquid. The consequent reduction of surface tension and viscosity allows the production of micrometric or nanometric particles of controlled size and distribution at a production rate up to one hundred times that of the traditional process. The new process was applied to particle generation from a very high molecular weight polyvinylpyrrolidone (PVP) and tested at different polymer percentages by weight and at different pressures. Repeatable microparticle diameters and distributions were obtained, ranging between 0.55 and 2.25 µm at PVP concentrations from 1 to 5% w/w and pressures between 80 and 120 bar.
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spelling pubmed-64190222019-04-02 Supercritical Assisted Electrospray: An Improved Micronization Process Baldino, Lucia Cardea, Stefano Reverchon, Ernesto Polymers (Basel) Article A new process is proposed that can largely improve classical electrospray (ESPR) atomization, thanks to the addition of supercritical CO(2) (SC-CO(2)) to the liquid mixture, in which a polymer is dissolved, forming an expanded liquid. The consequent reduction of surface tension and viscosity allows the production of micrometric or nanometric particles of controlled size and distribution at a production rate up to one hundred times that of the traditional process. The new process was applied to particle generation from a very high molecular weight polyvinylpyrrolidone (PVP) and tested at different polymer percentages by weight and at different pressures. Repeatable microparticle diameters and distributions were obtained, ranging between 0.55 and 2.25 µm at PVP concentrations from 1 to 5% w/w and pressures between 80 and 120 bar. MDPI 2019-02-02 /pmc/articles/PMC6419022/ /pubmed/30960228 http://dx.doi.org/10.3390/polym11020244 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baldino, Lucia
Cardea, Stefano
Reverchon, Ernesto
Supercritical Assisted Electrospray: An Improved Micronization Process
title Supercritical Assisted Electrospray: An Improved Micronization Process
title_full Supercritical Assisted Electrospray: An Improved Micronization Process
title_fullStr Supercritical Assisted Electrospray: An Improved Micronization Process
title_full_unstemmed Supercritical Assisted Electrospray: An Improved Micronization Process
title_short Supercritical Assisted Electrospray: An Improved Micronization Process
title_sort supercritical assisted electrospray: an improved micronization process
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419022/
https://www.ncbi.nlm.nih.gov/pubmed/30960228
http://dx.doi.org/10.3390/polym11020244
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