Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine
Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419173/ https://www.ncbi.nlm.nih.gov/pubmed/30960327 http://dx.doi.org/10.3390/polym11020341 |
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author | Li, Xiaoran Chen, Zhenni Zhang, Haimin Zhuang, Yan Shen, He Chen, Yanyan Zhao, Yannan Chen, Bing Xiao, Zhifeng Dai, Jianwu |
author_facet | Li, Xiaoran Chen, Zhenni Zhang, Haimin Zhuang, Yan Shen, He Chen, Yanyan Zhao, Yannan Chen, Bing Xiao, Zhifeng Dai, Jianwu |
author_sort | Li, Xiaoran |
collection | PubMed |
description | Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion on the fabrication of aligned scaffolds, followed by how biomolecular gradients can be immobilized on aligned scaffolds. In particular, we emphasize how electrospinning, freeze drying, and 3D printing technology can accomplish aligned topography and biomolecular gradients flexibly and robustly. We then highlight several applications of aligned scaffolds and biomolecular gradients in regenerative medicine including nerve, tendon/ligament, and tendon/ligament-to-bone insertion regeneration. Finally, we finish with conclusions and future perspectives on the use of aligned scaffolds with biomolecular gradients in regenerative medicine. |
format | Online Article Text |
id | pubmed-6419173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64191732019-04-02 Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine Li, Xiaoran Chen, Zhenni Zhang, Haimin Zhuang, Yan Shen, He Chen, Yanyan Zhao, Yannan Chen, Bing Xiao, Zhifeng Dai, Jianwu Polymers (Basel) Review Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion on the fabrication of aligned scaffolds, followed by how biomolecular gradients can be immobilized on aligned scaffolds. In particular, we emphasize how electrospinning, freeze drying, and 3D printing technology can accomplish aligned topography and biomolecular gradients flexibly and robustly. We then highlight several applications of aligned scaffolds and biomolecular gradients in regenerative medicine including nerve, tendon/ligament, and tendon/ligament-to-bone insertion regeneration. Finally, we finish with conclusions and future perspectives on the use of aligned scaffolds with biomolecular gradients in regenerative medicine. MDPI 2019-02-15 /pmc/articles/PMC6419173/ /pubmed/30960327 http://dx.doi.org/10.3390/polym11020341 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Xiaoran Chen, Zhenni Zhang, Haimin Zhuang, Yan Shen, He Chen, Yanyan Zhao, Yannan Chen, Bing Xiao, Zhifeng Dai, Jianwu Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine |
title | Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine |
title_full | Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine |
title_fullStr | Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine |
title_full_unstemmed | Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine |
title_short | Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine |
title_sort | aligned scaffolds with biomolecular gradients for regenerative medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419173/ https://www.ncbi.nlm.nih.gov/pubmed/30960327 http://dx.doi.org/10.3390/polym11020341 |
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