Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine

Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion o...

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Autores principales: Li, Xiaoran, Chen, Zhenni, Zhang, Haimin, Zhuang, Yan, Shen, He, Chen, Yanyan, Zhao, Yannan, Chen, Bing, Xiao, Zhifeng, Dai, Jianwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419173/
https://www.ncbi.nlm.nih.gov/pubmed/30960327
http://dx.doi.org/10.3390/polym11020341
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author Li, Xiaoran
Chen, Zhenni
Zhang, Haimin
Zhuang, Yan
Shen, He
Chen, Yanyan
Zhao, Yannan
Chen, Bing
Xiao, Zhifeng
Dai, Jianwu
author_facet Li, Xiaoran
Chen, Zhenni
Zhang, Haimin
Zhuang, Yan
Shen, He
Chen, Yanyan
Zhao, Yannan
Chen, Bing
Xiao, Zhifeng
Dai, Jianwu
author_sort Li, Xiaoran
collection PubMed
description Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion on the fabrication of aligned scaffolds, followed by how biomolecular gradients can be immobilized on aligned scaffolds. In particular, we emphasize how electrospinning, freeze drying, and 3D printing technology can accomplish aligned topography and biomolecular gradients flexibly and robustly. We then highlight several applications of aligned scaffolds and biomolecular gradients in regenerative medicine including nerve, tendon/ligament, and tendon/ligament-to-bone insertion regeneration. Finally, we finish with conclusions and future perspectives on the use of aligned scaffolds with biomolecular gradients in regenerative medicine.
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spelling pubmed-64191732019-04-02 Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine Li, Xiaoran Chen, Zhenni Zhang, Haimin Zhuang, Yan Shen, He Chen, Yanyan Zhao, Yannan Chen, Bing Xiao, Zhifeng Dai, Jianwu Polymers (Basel) Review Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion on the fabrication of aligned scaffolds, followed by how biomolecular gradients can be immobilized on aligned scaffolds. In particular, we emphasize how electrospinning, freeze drying, and 3D printing technology can accomplish aligned topography and biomolecular gradients flexibly and robustly. We then highlight several applications of aligned scaffolds and biomolecular gradients in regenerative medicine including nerve, tendon/ligament, and tendon/ligament-to-bone insertion regeneration. Finally, we finish with conclusions and future perspectives on the use of aligned scaffolds with biomolecular gradients in regenerative medicine. MDPI 2019-02-15 /pmc/articles/PMC6419173/ /pubmed/30960327 http://dx.doi.org/10.3390/polym11020341 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Xiaoran
Chen, Zhenni
Zhang, Haimin
Zhuang, Yan
Shen, He
Chen, Yanyan
Zhao, Yannan
Chen, Bing
Xiao, Zhifeng
Dai, Jianwu
Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine
title Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine
title_full Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine
title_fullStr Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine
title_full_unstemmed Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine
title_short Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine
title_sort aligned scaffolds with biomolecular gradients for regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419173/
https://www.ncbi.nlm.nih.gov/pubmed/30960327
http://dx.doi.org/10.3390/polym11020341
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