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Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery

The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and (1)H NMR were adopted to characterize and confirm the chemical structures of the obtained mPEG-PAAHPs. The temperature responsive behavior investigated by transmitt...

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Detalles Bibliográficos
Autores principales: Zhang, Guangyan, Jiang, Xulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419189/
https://www.ncbi.nlm.nih.gov/pubmed/30960299
http://dx.doi.org/10.3390/polym11020316
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author Zhang, Guangyan
Jiang, Xulin
author_facet Zhang, Guangyan
Jiang, Xulin
author_sort Zhang, Guangyan
collection PubMed
description The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and (1)H NMR were adopted to characterize and confirm the chemical structures of the obtained mPEG-PAAHPs. The temperature responsive behavior investigated by transmittance and dynamic light scattering showed that some of the obtained mPEG-PAAHPs exhibited obvious temperature responsiveness and could be used to prepare nanoparticles by quickly heating. Drug paclitaxel can be encapsulated into mPEG-PAAHP based nanoparticles with a high encapsulation efficiency up to 99% (corresponding to a drug loading content of around 9.9%). Dynamic light scattering results showed that the PTX-loaded nanoparticles had a mean size around 80 nm (PDI<0.2) and good stability in PBS with 150 mM ionic strength. In vitro cytotoxicity results showed that mPEG-PAAHP did not show any toxicity to HeLa cells, but the PTX-loaded nanoparticles based on mPEG-PAAHP exhibited obvious anti-cancer activity. Thus, the temperature responsive PEGylated polyaspartamide derivative mPEG-PAAHP may be a promising drug delivery system.
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spelling pubmed-64191892019-04-02 Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery Zhang, Guangyan Jiang, Xulin Polymers (Basel) Article The temperature responsive PEGylated polyaspartamide derivative, denoted as mPEG-PAAHP, was synthesized by the click reaction. FTIR and (1)H NMR were adopted to characterize and confirm the chemical structures of the obtained mPEG-PAAHPs. The temperature responsive behavior investigated by transmittance and dynamic light scattering showed that some of the obtained mPEG-PAAHPs exhibited obvious temperature responsiveness and could be used to prepare nanoparticles by quickly heating. Drug paclitaxel can be encapsulated into mPEG-PAAHP based nanoparticles with a high encapsulation efficiency up to 99% (corresponding to a drug loading content of around 9.9%). Dynamic light scattering results showed that the PTX-loaded nanoparticles had a mean size around 80 nm (PDI<0.2) and good stability in PBS with 150 mM ionic strength. In vitro cytotoxicity results showed that mPEG-PAAHP did not show any toxicity to HeLa cells, but the PTX-loaded nanoparticles based on mPEG-PAAHP exhibited obvious anti-cancer activity. Thus, the temperature responsive PEGylated polyaspartamide derivative mPEG-PAAHP may be a promising drug delivery system. MDPI 2019-02-13 /pmc/articles/PMC6419189/ /pubmed/30960299 http://dx.doi.org/10.3390/polym11020316 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Guangyan
Jiang, Xulin
Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery
title Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery
title_full Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery
title_fullStr Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery
title_full_unstemmed Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery
title_short Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery
title_sort temperature responsive nanoparticles based on pegylated polyaspartamide derivatives for drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419189/
https://www.ncbi.nlm.nih.gov/pubmed/30960299
http://dx.doi.org/10.3390/polym11020316
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