Fabrication and Application of Dual-Modality Polymer Nanoparticles Based on an Aggregation-Induced Emission-Active Fluorescent Molecule and Magnetic Fe(3)O(4)

Fluorescent magnetic nanoparticles (NPs) utilized for imaging hold great promise for biomedical applications, but it remains a challenging task. Here, we report novel dual-modality NPs using an aggregation-induced emission (AIE)-active and near-infrared (NIR) emissive dye (TPAS) and magnetic Fe(3)O(...

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Detalles Bibliográficos
Autores principales: Wang, Lingyun, Huang, Meiying, Tang, Hao, Cao, Derong, Zhao, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419270/
https://www.ncbi.nlm.nih.gov/pubmed/30960204
http://dx.doi.org/10.3390/polym11020220
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author Wang, Lingyun
Huang, Meiying
Tang, Hao
Cao, Derong
Zhao, Yu
author_facet Wang, Lingyun
Huang, Meiying
Tang, Hao
Cao, Derong
Zhao, Yu
author_sort Wang, Lingyun
collection PubMed
description Fluorescent magnetic nanoparticles (NPs) utilized for imaging hold great promise for biomedical applications, but it remains a challenging task. Here, we report novel dual-modality NPs using an aggregation-induced emission (AIE)-active and near-infrared (NIR) emissive dye (TPAS) and magnetic Fe(3)O(4) as the core, and biocompatible polymer Pluronic F-127 as the encapsulation matrix by self-assembly procedures. The obtained fluorescent-magnetic AIE NPs have both high fluorescence quantum yield (13.8%) at 700 nm and high magnetic saturation value. With good photostability and biocompatibility, the resulting NPs show effective MRI ability, but also a stain in cytoplasm with a strong NIR fluorescent signal.
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spelling pubmed-64192702019-04-02 Fabrication and Application of Dual-Modality Polymer Nanoparticles Based on an Aggregation-Induced Emission-Active Fluorescent Molecule and Magnetic Fe(3)O(4) Wang, Lingyun Huang, Meiying Tang, Hao Cao, Derong Zhao, Yu Polymers (Basel) Article Fluorescent magnetic nanoparticles (NPs) utilized for imaging hold great promise for biomedical applications, but it remains a challenging task. Here, we report novel dual-modality NPs using an aggregation-induced emission (AIE)-active and near-infrared (NIR) emissive dye (TPAS) and magnetic Fe(3)O(4) as the core, and biocompatible polymer Pluronic F-127 as the encapsulation matrix by self-assembly procedures. The obtained fluorescent-magnetic AIE NPs have both high fluorescence quantum yield (13.8%) at 700 nm and high magnetic saturation value. With good photostability and biocompatibility, the resulting NPs show effective MRI ability, but also a stain in cytoplasm with a strong NIR fluorescent signal. MDPI 2019-01-28 /pmc/articles/PMC6419270/ /pubmed/30960204 http://dx.doi.org/10.3390/polym11020220 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Lingyun
Huang, Meiying
Tang, Hao
Cao, Derong
Zhao, Yu
Fabrication and Application of Dual-Modality Polymer Nanoparticles Based on an Aggregation-Induced Emission-Active Fluorescent Molecule and Magnetic Fe(3)O(4)
title Fabrication and Application of Dual-Modality Polymer Nanoparticles Based on an Aggregation-Induced Emission-Active Fluorescent Molecule and Magnetic Fe(3)O(4)
title_full Fabrication and Application of Dual-Modality Polymer Nanoparticles Based on an Aggregation-Induced Emission-Active Fluorescent Molecule and Magnetic Fe(3)O(4)
title_fullStr Fabrication and Application of Dual-Modality Polymer Nanoparticles Based on an Aggregation-Induced Emission-Active Fluorescent Molecule and Magnetic Fe(3)O(4)
title_full_unstemmed Fabrication and Application of Dual-Modality Polymer Nanoparticles Based on an Aggregation-Induced Emission-Active Fluorescent Molecule and Magnetic Fe(3)O(4)
title_short Fabrication and Application of Dual-Modality Polymer Nanoparticles Based on an Aggregation-Induced Emission-Active Fluorescent Molecule and Magnetic Fe(3)O(4)
title_sort fabrication and application of dual-modality polymer nanoparticles based on an aggregation-induced emission-active fluorescent molecule and magnetic fe(3)o(4)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419270/
https://www.ncbi.nlm.nih.gov/pubmed/30960204
http://dx.doi.org/10.3390/polym11020220
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