Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A)

Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT(1A) receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection...

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Detalles Bibliográficos
Autores principales: Chaturvedi, Shubhra, Lal, Sangeeta, Sen, Prasenjit, Mishra, Anil K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419312/
https://www.ncbi.nlm.nih.gov/pubmed/30880954
http://dx.doi.org/10.2147/IJN.S125009
Descripción
Sumario:Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT(1A) receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities.

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