Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A)

Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT(1A) receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection...

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Autores principales: Chaturvedi, Shubhra, Lal, Sangeeta, Sen, Prasenjit, Mishra, Anil K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419312/
https://www.ncbi.nlm.nih.gov/pubmed/30880954
http://dx.doi.org/10.2147/IJN.S125009
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author Chaturvedi, Shubhra
Lal, Sangeeta
Sen, Prasenjit
Mishra, Anil K
author_facet Chaturvedi, Shubhra
Lal, Sangeeta
Sen, Prasenjit
Mishra, Anil K
author_sort Chaturvedi, Shubhra
collection PubMed
description Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT(1A) receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities.
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spelling pubmed-64193122019-03-16 Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A) Chaturvedi, Shubhra Lal, Sangeeta Sen, Prasenjit Mishra, Anil K Int J Nanomedicine Short Report Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT(1A) receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities. Dove Medical Press 2018-03-15 /pmc/articles/PMC6419312/ /pubmed/30880954 http://dx.doi.org/10.2147/IJN.S125009 Text en © 2018 Chaturvedi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Short Report
Chaturvedi, Shubhra
Lal, Sangeeta
Sen, Prasenjit
Mishra, Anil K
Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A)
title Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A)
title_full Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A)
title_fullStr Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A)
title_full_unstemmed Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A)
title_short Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT(1A)
title_sort synthesis, docking, and preliminary in vitro/in vivo evaluation of mpp-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5ht(1a)
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419312/
https://www.ncbi.nlm.nih.gov/pubmed/30880954
http://dx.doi.org/10.2147/IJN.S125009
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