Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma

A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit f...

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Autores principales: Przybyl, Joanna, van de Rijn, Matt, Rutkowski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419438/
https://www.ncbi.nlm.nih.gov/pubmed/30871572
http://dx.doi.org/10.1186/s13000-019-0800-x
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author Przybyl, Joanna
van de Rijn, Matt
Rutkowski, Piotr
author_facet Przybyl, Joanna
van de Rijn, Matt
Rutkowski, Piotr
author_sort Przybyl, Joanna
collection PubMed
description A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit from a non-invasive monitoring of tumor burden by liquid biopsies. However, given the low detection rate of SS18-SSX1/2 in circulation, we conclude that alternative markers other than the tumor-type specific fusion transcripts should be considered.
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spelling pubmed-64194382019-03-27 Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma Przybyl, Joanna van de Rijn, Matt Rutkowski, Piotr Diagn Pathol Commentary A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit from a non-invasive monitoring of tumor burden by liquid biopsies. However, given the low detection rate of SS18-SSX1/2 in circulation, we conclude that alternative markers other than the tumor-type specific fusion transcripts should be considered. BioMed Central 2019-03-14 /pmc/articles/PMC6419438/ /pubmed/30871572 http://dx.doi.org/10.1186/s13000-019-0800-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Przybyl, Joanna
van de Rijn, Matt
Rutkowski, Piotr
Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
title Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
title_full Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
title_fullStr Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
title_full_unstemmed Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
title_short Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
title_sort detection of ss18-ssx1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419438/
https://www.ncbi.nlm.nih.gov/pubmed/30871572
http://dx.doi.org/10.1186/s13000-019-0800-x
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AT rutkowskipiotr detectionofss18ssx12fusiontranscriptsincirculatingtumorcellsofpatientswithsynovialsarcoma

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