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p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance

Tumor cells with p53 inactivation frequently exhibit chemotherapy resistance, which poses a longstanding challenge to cancer treatment. Here we unveiled a previously unrecognized role of TET2 in mediating p53-loss induced chemotherapy resistance in colon cancer. Deletion of TET2 in p53KO colon cance...

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Detalles Bibliográficos
Autores principales:	Zhang, Jixiang, Tan, Peng, Guo, Lei, Gong, Jing, Ma, Jingjing, Li, Jia, Lee, Minjung, Fang, Shaohai, Jing, Ji, Johnson, Gavin, Sun, Deqiang, Cao, Wen-ming, Dashwood, Roderick, Han, Leng, Zhou, Yubin, Dong, Wei-Guo, Huang, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419514/ https://www.ncbi.nlm.nih.gov/pubmed/30390073 http://dx.doi.org/10.1038/s41388-018-0524-5

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