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Are Regulation and Innovation Priorities Serving Public Health Needs?

A host of challenges confront healthcare authorities worldwide. Topping the list is the demand for innovative new medicines to treat a range of both infectious and non-communicable diseases, while containing spiraling healthcare costs. The challenge is particularly great in therapeutic areas where,...

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Detalles Bibliográficos
Autores principales: Milne, Christopher-Paul, Kaitin, Kenneth I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419525/
https://www.ncbi.nlm.nih.gov/pubmed/30906258
http://dx.doi.org/10.3389/fphar.2019.00144
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author Milne, Christopher-Paul
Kaitin, Kenneth I.
author_facet Milne, Christopher-Paul
Kaitin, Kenneth I.
author_sort Milne, Christopher-Paul
collection PubMed
description A host of challenges confront healthcare authorities worldwide. Topping the list is the demand for innovative new medicines to treat a range of both infectious and non-communicable diseases, while containing spiraling healthcare costs. The challenge is particularly great in therapeutic areas where, despite significant medical need and economic impact, the technical challenges and commercial risk of development serve as disincentives to drug sponsors. These areas include cardiovascular diseases as well as diseases and disorders of the central nervous system. Currently, the development and approval of new active substances, with its disproportionate focus on oncology, is not in alignment with healthcare needs in most geographic regions. In this article, we discuss the origins of this misalignment and suggest various approaches to address healthcare needs going forward.
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spelling pubmed-64195252019-03-22 Are Regulation and Innovation Priorities Serving Public Health Needs? Milne, Christopher-Paul Kaitin, Kenneth I. Front Pharmacol Pharmacology A host of challenges confront healthcare authorities worldwide. Topping the list is the demand for innovative new medicines to treat a range of both infectious and non-communicable diseases, while containing spiraling healthcare costs. The challenge is particularly great in therapeutic areas where, despite significant medical need and economic impact, the technical challenges and commercial risk of development serve as disincentives to drug sponsors. These areas include cardiovascular diseases as well as diseases and disorders of the central nervous system. Currently, the development and approval of new active substances, with its disproportionate focus on oncology, is not in alignment with healthcare needs in most geographic regions. In this article, we discuss the origins of this misalignment and suggest various approaches to address healthcare needs going forward. Frontiers Media S.A. 2019-03-08 /pmc/articles/PMC6419525/ /pubmed/30906258 http://dx.doi.org/10.3389/fphar.2019.00144 Text en Copyright © 2019 Milne and Kaitin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Milne, Christopher-Paul
Kaitin, Kenneth I.
Are Regulation and Innovation Priorities Serving Public Health Needs?
title Are Regulation and Innovation Priorities Serving Public Health Needs?
title_full Are Regulation and Innovation Priorities Serving Public Health Needs?
title_fullStr Are Regulation and Innovation Priorities Serving Public Health Needs?
title_full_unstemmed Are Regulation and Innovation Priorities Serving Public Health Needs?
title_short Are Regulation and Innovation Priorities Serving Public Health Needs?
title_sort are regulation and innovation priorities serving public health needs?
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419525/
https://www.ncbi.nlm.nih.gov/pubmed/30906258
http://dx.doi.org/10.3389/fphar.2019.00144
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