Neuronal overexpression of Alzheimer's disease and Down's syndrome associated DYRK1A/minibrain gene alters motor decline, neurodegeneration and synaptic plasticity in Drosophila

Down syndrome (DS) is characterised by abnormal cognitive and motor development, and later in life by progressive Alzheimer's disease (AD)-like dementia, neuropathology, declining motor function and shorter life expectancy. It is caused by trisomy of chromosome 21 (Hsa21), but how individual Hs...

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Detalles Bibliográficos
Autores principales: Lowe, Simon A., Usowicz, Maria M., Hodge, James J.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419573/
https://www.ncbi.nlm.nih.gov/pubmed/30703437
http://dx.doi.org/10.1016/j.nbd.2019.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419573/
https://www.ncbi.nlm.nih.gov/pubmed/30703437
http://dx.doi.org/10.1016/j.nbd.2019.01.017

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