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Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer

BACKGROUND: Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to treatment inevitably occurs. Given lipid metabolic reprogramming is widely known...

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Detalles Bibliográficos
Autores principales:	Huang, Quanfu, Wang, Qiuguo, Li, Dong, Wei, Xiao, Jia, Yijuan, Zhang, Zheng, Ai, Bo, Cao, Xiaonian, Guo, Tao, Liao, Yongde
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419820/ https://www.ncbi.nlm.nih.gov/pubmed/30876460 http://dx.doi.org/10.1186/s13046-019-1120-4

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