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Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss

BACKGROUND: Ovarian reserve testing is not routinely performed in the evaluation of recurrent pregnancy loss (RPL). The objective of this study was to determine if AMH levels are predictive of live birth rate in RPL patients pursuing expectant management (EM). METHODS: Retrospective cohort study of...

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Autores principales: Murugappan, Gayathree, Shahine, Lora, Lathi, Ruth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419824/
https://www.ncbi.nlm.nih.gov/pubmed/30923623
http://dx.doi.org/10.1186/s40738-019-0054-z
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author Murugappan, Gayathree
Shahine, Lora
Lathi, Ruth B.
author_facet Murugappan, Gayathree
Shahine, Lora
Lathi, Ruth B.
author_sort Murugappan, Gayathree
collection PubMed
description BACKGROUND: Ovarian reserve testing is not routinely performed in the evaluation of recurrent pregnancy loss (RPL). The objective of this study was to determine if AMH levels are predictive of live birth rate in RPL patients pursuing expectant management (EM). METHODS: Retrospective cohort study of RPL patients. Patients tried to conceive spontaneously for 12 calendar months or until they achieved a live birth, whichever occurred first. All patients with the intent to conceive were included regardless of final outcome. RESULTS: One hundred fifty-five RPL patients treated from 2009 to 2017 were included. In a univariate logistic regression, AMH < 1 ng/mL was associated with decreased likelihood of live birth (OR 0.38; CI 0.16–0.87, p = 0.03) and increasing age (OR 0.91; CI 0.83–0.99, p = 0.04). Likelihood of live birth was not significantly associated with BMI (OR 1.21; CI 0.83–1.77, p = 0.31), three or four or more prior pregnancy losses (OR 0.93; CI 0.40–2.22, p = 0.87 and OR 0.52; CI 0.19–1.42, p = 0.20, respectively) and prior live births (OR 1.00; CI 0.48–2.08, p = 0.99). AMH < 1 ng/mL was shown to be a stronger predictor of live birth than age using a multivariate model adjusting for age, AMH, and time to conception. CONCLUSIONS: AMH < 1 ng/mL is associated with decreased likelihood of live birth among RPL patients pursuing EM, and may be a stronger predictor of live birth than age in this population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40738-019-0054-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-64198242019-03-28 Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss Murugappan, Gayathree Shahine, Lora Lathi, Ruth B. Fertil Res Pract Research Article BACKGROUND: Ovarian reserve testing is not routinely performed in the evaluation of recurrent pregnancy loss (RPL). The objective of this study was to determine if AMH levels are predictive of live birth rate in RPL patients pursuing expectant management (EM). METHODS: Retrospective cohort study of RPL patients. Patients tried to conceive spontaneously for 12 calendar months or until they achieved a live birth, whichever occurred first. All patients with the intent to conceive were included regardless of final outcome. RESULTS: One hundred fifty-five RPL patients treated from 2009 to 2017 were included. In a univariate logistic regression, AMH < 1 ng/mL was associated with decreased likelihood of live birth (OR 0.38; CI 0.16–0.87, p = 0.03) and increasing age (OR 0.91; CI 0.83–0.99, p = 0.04). Likelihood of live birth was not significantly associated with BMI (OR 1.21; CI 0.83–1.77, p = 0.31), three or four or more prior pregnancy losses (OR 0.93; CI 0.40–2.22, p = 0.87 and OR 0.52; CI 0.19–1.42, p = 0.20, respectively) and prior live births (OR 1.00; CI 0.48–2.08, p = 0.99). AMH < 1 ng/mL was shown to be a stronger predictor of live birth than age using a multivariate model adjusting for age, AMH, and time to conception. CONCLUSIONS: AMH < 1 ng/mL is associated with decreased likelihood of live birth among RPL patients pursuing EM, and may be a stronger predictor of live birth than age in this population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40738-019-0054-z) contains supplementary material, which is available to authorized users. BioMed Central 2019-03-15 /pmc/articles/PMC6419824/ /pubmed/30923623 http://dx.doi.org/10.1186/s40738-019-0054-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Murugappan, Gayathree
Shahine, Lora
Lathi, Ruth B.
Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss
title Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss
title_full Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss
title_fullStr Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss
title_full_unstemmed Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss
title_short Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss
title_sort antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419824/
https://www.ncbi.nlm.nih.gov/pubmed/30923623
http://dx.doi.org/10.1186/s40738-019-0054-z
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