The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes

BACKGROUND: Foot infection is a major complication of diabetes mellitus (DM) and its agents are usually polymicrobial. This study aims to describe the agent and determine the association between polymicrobial infections and the severity of diabetic foot infections (DFI) and their outcomes. METHODS:...

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Autores principales: Hitam, Sharifah Aisyah Syed, Hassan, Siti Asma’, Maning, Nurahan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Penerbit Universiti Sains Malaysia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419864/
https://www.ncbi.nlm.nih.gov/pubmed/30914898
http://dx.doi.org/10.21315/mjms2019.26.1.10
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author Hitam, Sharifah Aisyah Syed
Hassan, Siti Asma’
Maning, Nurahan
author_facet Hitam, Sharifah Aisyah Syed
Hassan, Siti Asma’
Maning, Nurahan
author_sort Hitam, Sharifah Aisyah Syed
collection PubMed
description BACKGROUND: Foot infection is a major complication of diabetes mellitus (DM) and its agents are usually polymicrobial. This study aims to describe the agent and determine the association between polymicrobial infections and the severity of diabetic foot infections (DFI) and their outcomes. METHODS: This retrospective cohort study was conducted during one year and it involved 104 patients. Their records were reviewed and assessed. The causative agents and its sensitivity pattern were noted. The results were presented as descriptive statistic and analysed. RESULTS: A total of 133 microorganisms were isolated with 1.28 microorganisms per lesion. The microorganism isolated were 62% (n = 83) GN (Gram-negative) and 38% (n = 50) GP (Gram-positive). GN microorganisms include Pseudomonas spp (28%), Proteus spp (11%), Klebsiella spp (8%) and E. coli (4%). Staphylococcus aureus (54%) was predominant among GP, followed by Group B Streptococci (26%) and Enterococcus spp (6%). Thirty patients (28.8%) had polymicrobial infections. The association between the quantity of microorganisms and severity of DFI was significant. Among severe DFI cases, 77.8% with polymicrobial microorganisms underwent amputation compared to 33.3% with monomicrobial infection. CONCLUSION: GN microorganisms were predominantly isolated from DFIs and remained sensitive to widely used agents. Polymicrobial infections were associated with DFI severity.
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spelling pubmed-64198642019-03-26 The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes Hitam, Sharifah Aisyah Syed Hassan, Siti Asma’ Maning, Nurahan Malays J Med Sci Original Article BACKGROUND: Foot infection is a major complication of diabetes mellitus (DM) and its agents are usually polymicrobial. This study aims to describe the agent and determine the association between polymicrobial infections and the severity of diabetic foot infections (DFI) and their outcomes. METHODS: This retrospective cohort study was conducted during one year and it involved 104 patients. Their records were reviewed and assessed. The causative agents and its sensitivity pattern were noted. The results were presented as descriptive statistic and analysed. RESULTS: A total of 133 microorganisms were isolated with 1.28 microorganisms per lesion. The microorganism isolated were 62% (n = 83) GN (Gram-negative) and 38% (n = 50) GP (Gram-positive). GN microorganisms include Pseudomonas spp (28%), Proteus spp (11%), Klebsiella spp (8%) and E. coli (4%). Staphylococcus aureus (54%) was predominant among GP, followed by Group B Streptococci (26%) and Enterococcus spp (6%). Thirty patients (28.8%) had polymicrobial infections. The association between the quantity of microorganisms and severity of DFI was significant. Among severe DFI cases, 77.8% with polymicrobial microorganisms underwent amputation compared to 33.3% with monomicrobial infection. CONCLUSION: GN microorganisms were predominantly isolated from DFIs and remained sensitive to widely used agents. Polymicrobial infections were associated with DFI severity. Penerbit Universiti Sains Malaysia 2019-01 2019-02-28 /pmc/articles/PMC6419864/ /pubmed/30914898 http://dx.doi.org/10.21315/mjms2019.26.1.10 Text en © Penerbit Universiti Sains Malaysia, 2019 This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Hitam, Sharifah Aisyah Syed
Hassan, Siti Asma’
Maning, Nurahan
The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes
title The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes
title_full The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes
title_fullStr The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes
title_full_unstemmed The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes
title_short The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes
title_sort significant association between polymicrobial diabetic foot infection and its severity and outcomes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419864/
https://www.ncbi.nlm.nih.gov/pubmed/30914898
http://dx.doi.org/10.21315/mjms2019.26.1.10
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