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Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients

BACKGROUND: Neuroimaging is increasingly used to locate the lesion that causes cerebral palsy (CP) and its extent in the brains of CP patients. Conventional structural magnetic resonance imaging (MRI) does not indicate the connectional pattern of white matter; however, with the help of diffusion MRI...

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Autores principales: Samsir, Safwan, Zakaria, Rahimah, Razak, Salmi Abdul, Ismail, Mohamed Saat, Rahim, Mohd Zulkifli Abdul, Lin, Chia-Shu, Osman, Nik Mohammad Faez Nik, Asri, Mohammad Afiq, Ahmad, Asma Hayati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Penerbit Universiti Sains Malaysia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419886/
https://www.ncbi.nlm.nih.gov/pubmed/30914864
http://dx.doi.org/10.21315/mjms2018.25.5.7
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author Samsir, Safwan
Zakaria, Rahimah
Razak, Salmi Abdul
Ismail, Mohamed Saat
Rahim, Mohd Zulkifli Abdul
Lin, Chia-Shu
Osman, Nik Mohammad Faez Nik
Asri, Mohammad Afiq
Ahmad, Asma Hayati
author_facet Samsir, Safwan
Zakaria, Rahimah
Razak, Salmi Abdul
Ismail, Mohamed Saat
Rahim, Mohd Zulkifli Abdul
Lin, Chia-Shu
Osman, Nik Mohammad Faez Nik
Asri, Mohammad Afiq
Ahmad, Asma Hayati
author_sort Samsir, Safwan
collection PubMed
description BACKGROUND: Neuroimaging is increasingly used to locate the lesion that causes cerebral palsy (CP) and its extent in the brains of CP patients. Conventional structural magnetic resonance imaging (MRI) does not indicate the connectional pattern of white matter; however, with the help of diffusion MRI, fibre tracking of white matter can be done. METHODS: We used diffusion MRI and probabilistic tractography to identify the putative white matter connectivity in the brains of 10 CP patients. We tracked the corticospinal tract (CST) of the patients’ upper and lower limbs and calculated the white matter connectivity, as indexed by streamlines representing the probability of connection of the CST. RESULTS: Our results show that diffusion MRI with probabilistic tractography, while having some relation with the clinical diagnosis of CP, reveals a high degree of individual variation in the streamlines representing the CST for upper and lower limbs. CONCLUSION: Diffusion MRI with probabilistic tractography provides the state of connectivity from lesioned areas to other parts of the brain and is potentially beneficial to be used as an adjunct to the clinical management of CP, providing a means to monitor intervention outcomes.
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spelling pubmed-64198862019-03-26 Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients Samsir, Safwan Zakaria, Rahimah Razak, Salmi Abdul Ismail, Mohamed Saat Rahim, Mohd Zulkifli Abdul Lin, Chia-Shu Osman, Nik Mohammad Faez Nik Asri, Mohammad Afiq Ahmad, Asma Hayati Malays J Med Sci Original Article BACKGROUND: Neuroimaging is increasingly used to locate the lesion that causes cerebral palsy (CP) and its extent in the brains of CP patients. Conventional structural magnetic resonance imaging (MRI) does not indicate the connectional pattern of white matter; however, with the help of diffusion MRI, fibre tracking of white matter can be done. METHODS: We used diffusion MRI and probabilistic tractography to identify the putative white matter connectivity in the brains of 10 CP patients. We tracked the corticospinal tract (CST) of the patients’ upper and lower limbs and calculated the white matter connectivity, as indexed by streamlines representing the probability of connection of the CST. RESULTS: Our results show that diffusion MRI with probabilistic tractography, while having some relation with the clinical diagnosis of CP, reveals a high degree of individual variation in the streamlines representing the CST for upper and lower limbs. CONCLUSION: Diffusion MRI with probabilistic tractography provides the state of connectivity from lesioned areas to other parts of the brain and is potentially beneficial to be used as an adjunct to the clinical management of CP, providing a means to monitor intervention outcomes. Penerbit Universiti Sains Malaysia 2018-09 2018-10-30 /pmc/articles/PMC6419886/ /pubmed/30914864 http://dx.doi.org/10.21315/mjms2018.25.5.7 Text en © Penerbit Universiti Sains Malaysia, 2018 This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Samsir, Safwan
Zakaria, Rahimah
Razak, Salmi Abdul
Ismail, Mohamed Saat
Rahim, Mohd Zulkifli Abdul
Lin, Chia-Shu
Osman, Nik Mohammad Faez Nik
Asri, Mohammad Afiq
Ahmad, Asma Hayati
Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients
title Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients
title_full Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients
title_fullStr Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients
title_full_unstemmed Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients
title_short Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients
title_sort characterisation of the corticospinal tract using diffusion magnetic resonance imaging in unilateral and bilateral cerebral palsy patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419886/
https://www.ncbi.nlm.nih.gov/pubmed/30914864
http://dx.doi.org/10.21315/mjms2018.25.5.7
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