Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways

Several lines of evidence point to a compromised proteostasis associated with a reduction of the Ubiquitin Proteasome System (UPS) activity in patients affected by Alzheimer's Disease (AD) and suggest that the amyloid β peptide (Aβ) is an important player in the game. Inspired also by many repo...

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Detalles Bibliográficos
Autores principales: Bellia, F., Lanza, V., García-Viñuales, S., Ahmed, I. M. M., Pietropaolo, A., Iacobucci, C., Malgieri, G., D'Abrosca, G., Fattorusso, R., Nicoletti, V. G., Sbardella, D., Tundo, G. R., Coletta, M., Pirone, L., Pedone, E., Calcagno, D., Grasso, G., Milardi, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419943/
https://www.ncbi.nlm.nih.gov/pubmed/30996991
http://dx.doi.org/10.1039/c8sc03394c

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