Cargando…
Genomic insights into the 2016-2017 Yemeni cholera epidemic
Yemen is currently experiencing the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported1. We investigated the phylogenetic relationships, pathogenesis, and antimicrobial resistance determina...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420076/ https://www.ncbi.nlm.nih.gov/pubmed/30602788 http://dx.doi.org/10.1038/s41586-018-0818-3 |
_version_ | 1783404052813447168 |
---|---|
author | Weill, François-Xavier Domman, Daryl Njamkepo, Elisabeth Almesbahi, Abdullrahman A. Naji, Mona Nasher, Samar Saeed Rakesh, Ankur Assiri, Abdullah M. Sharma, Naresh Chand Kariuki, Samuel Pourshafie, Mohammad Reza Rauzier, Jean Abubakar, Abdinasir Carter, Jane Y. Wamala, Joseph F. Seguin, Caroline Bouchier, Christiane Malliavin, Thérèse Bakhshi, Bita Abulmaali, Hayder H. N. Kumar, Dhirendra Njoroge, Samuel M. Malik, Mamunur Rahman Kiiru, John Luquero, Francisco J. Azman, Andrew S. Ramamurthy, Thandavarayan Thomson, Nicholas R. Quilici, Marie-Laure |
author_facet | Weill, François-Xavier Domman, Daryl Njamkepo, Elisabeth Almesbahi, Abdullrahman A. Naji, Mona Nasher, Samar Saeed Rakesh, Ankur Assiri, Abdullah M. Sharma, Naresh Chand Kariuki, Samuel Pourshafie, Mohammad Reza Rauzier, Jean Abubakar, Abdinasir Carter, Jane Y. Wamala, Joseph F. Seguin, Caroline Bouchier, Christiane Malliavin, Thérèse Bakhshi, Bita Abulmaali, Hayder H. N. Kumar, Dhirendra Njoroge, Samuel M. Malik, Mamunur Rahman Kiiru, John Luquero, Francisco J. Azman, Andrew S. Ramamurthy, Thandavarayan Thomson, Nicholas R. Quilici, Marie-Laure |
author_sort | Weill, François-Xavier |
collection | PubMed |
description | Yemen is currently experiencing the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported1. We investigated the phylogenetic relationships, pathogenesis, and antimicrobial resistance determinants by sequencing the genomes of Vibrio cholerae isolates from the Yemen epidemic and recent isolates from neighbouring regions. These 116 genomic sequences were placed within the phylogenetic context of a global collection of 1087 seventh pandemic V. cholerae serogroup O1 and O139 biotype El Tor isolates [2–4]. We show that the Yemeni isolates collected during the two epidemiological waves of the epidemic [1], —the first between September 28(th) 2016 and April 23(rd) 2017 (25,839 suspected cases) and the second beginning on April 24(th), 2017 (more than one million suspected cases), — are seventh pandemic V. cholerae O1 El Tor (7PET) serotype Ogawa isolates from a single sublineage. Using genomic approaches, we link the Yemen epidemic to global radiations of pandemic V. cholerae and show that this sublineage originated from South Asia and that it caused outbreaks in East Africa before appearing in Yemen. We also show that the Yemeni isolates are susceptible to several antibiotics commonly used to treat cholera, and to polymyxins, resistance to which is used as a marker of the El Tor biotype. |
format | Online Article Text |
id | pubmed-6420076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-64200762019-07-02 Genomic insights into the 2016-2017 Yemeni cholera epidemic Weill, François-Xavier Domman, Daryl Njamkepo, Elisabeth Almesbahi, Abdullrahman A. Naji, Mona Nasher, Samar Saeed Rakesh, Ankur Assiri, Abdullah M. Sharma, Naresh Chand Kariuki, Samuel Pourshafie, Mohammad Reza Rauzier, Jean Abubakar, Abdinasir Carter, Jane Y. Wamala, Joseph F. Seguin, Caroline Bouchier, Christiane Malliavin, Thérèse Bakhshi, Bita Abulmaali, Hayder H. N. Kumar, Dhirendra Njoroge, Samuel M. Malik, Mamunur Rahman Kiiru, John Luquero, Francisco J. Azman, Andrew S. Ramamurthy, Thandavarayan Thomson, Nicholas R. Quilici, Marie-Laure Nature Article Yemen is currently experiencing the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported1. We investigated the phylogenetic relationships, pathogenesis, and antimicrobial resistance determinants by sequencing the genomes of Vibrio cholerae isolates from the Yemen epidemic and recent isolates from neighbouring regions. These 116 genomic sequences were placed within the phylogenetic context of a global collection of 1087 seventh pandemic V. cholerae serogroup O1 and O139 biotype El Tor isolates [2–4]. We show that the Yemeni isolates collected during the two epidemiological waves of the epidemic [1], —the first between September 28(th) 2016 and April 23(rd) 2017 (25,839 suspected cases) and the second beginning on April 24(th), 2017 (more than one million suspected cases), — are seventh pandemic V. cholerae O1 El Tor (7PET) serotype Ogawa isolates from a single sublineage. Using genomic approaches, we link the Yemen epidemic to global radiations of pandemic V. cholerae and show that this sublineage originated from South Asia and that it caused outbreaks in East Africa before appearing in Yemen. We also show that the Yemeni isolates are susceptible to several antibiotics commonly used to treat cholera, and to polymyxins, resistance to which is used as a marker of the El Tor biotype. 2019-01-02 2019-01-10 /pmc/articles/PMC6420076/ /pubmed/30602788 http://dx.doi.org/10.1038/s41586-018-0818-3 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Weill, François-Xavier Domman, Daryl Njamkepo, Elisabeth Almesbahi, Abdullrahman A. Naji, Mona Nasher, Samar Saeed Rakesh, Ankur Assiri, Abdullah M. Sharma, Naresh Chand Kariuki, Samuel Pourshafie, Mohammad Reza Rauzier, Jean Abubakar, Abdinasir Carter, Jane Y. Wamala, Joseph F. Seguin, Caroline Bouchier, Christiane Malliavin, Thérèse Bakhshi, Bita Abulmaali, Hayder H. N. Kumar, Dhirendra Njoroge, Samuel M. Malik, Mamunur Rahman Kiiru, John Luquero, Francisco J. Azman, Andrew S. Ramamurthy, Thandavarayan Thomson, Nicholas R. Quilici, Marie-Laure Genomic insights into the 2016-2017 Yemeni cholera epidemic |
title | Genomic insights into the 2016-2017 Yemeni cholera
epidemic |
title_full | Genomic insights into the 2016-2017 Yemeni cholera
epidemic |
title_fullStr | Genomic insights into the 2016-2017 Yemeni cholera
epidemic |
title_full_unstemmed | Genomic insights into the 2016-2017 Yemeni cholera
epidemic |
title_short | Genomic insights into the 2016-2017 Yemeni cholera
epidemic |
title_sort | genomic insights into the 2016-2017 yemeni cholera
epidemic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420076/ https://www.ncbi.nlm.nih.gov/pubmed/30602788 http://dx.doi.org/10.1038/s41586-018-0818-3 |
work_keys_str_mv | AT weillfrancoisxavier genomicinsightsintothe20162017yemenicholeraepidemic AT dommandaryl genomicinsightsintothe20162017yemenicholeraepidemic AT njamkepoelisabeth genomicinsightsintothe20162017yemenicholeraepidemic AT almesbahiabdullrahmana genomicinsightsintothe20162017yemenicholeraepidemic AT najimona genomicinsightsintothe20162017yemenicholeraepidemic AT nashersamarsaeed genomicinsightsintothe20162017yemenicholeraepidemic AT rakeshankur genomicinsightsintothe20162017yemenicholeraepidemic AT assiriabdullahm genomicinsightsintothe20162017yemenicholeraepidemic AT sharmanareshchand genomicinsightsintothe20162017yemenicholeraepidemic AT kariukisamuel genomicinsightsintothe20162017yemenicholeraepidemic AT pourshafiemohammadreza genomicinsightsintothe20162017yemenicholeraepidemic AT rauzierjean genomicinsightsintothe20162017yemenicholeraepidemic AT abubakarabdinasir genomicinsightsintothe20162017yemenicholeraepidemic AT carterjaney genomicinsightsintothe20162017yemenicholeraepidemic AT wamalajosephf genomicinsightsintothe20162017yemenicholeraepidemic AT seguincaroline genomicinsightsintothe20162017yemenicholeraepidemic AT bouchierchristiane genomicinsightsintothe20162017yemenicholeraepidemic AT malliavintherese genomicinsightsintothe20162017yemenicholeraepidemic AT bakhshibita genomicinsightsintothe20162017yemenicholeraepidemic AT abulmaalihayderhn genomicinsightsintothe20162017yemenicholeraepidemic AT kumardhirendra genomicinsightsintothe20162017yemenicholeraepidemic AT njorogesamuelm genomicinsightsintothe20162017yemenicholeraepidemic AT malikmamunurrahman genomicinsightsintothe20162017yemenicholeraepidemic AT kiirujohn genomicinsightsintothe20162017yemenicholeraepidemic AT luquerofranciscoj genomicinsightsintothe20162017yemenicholeraepidemic AT azmanandrews genomicinsightsintothe20162017yemenicholeraepidemic AT ramamurthythandavarayan genomicinsightsintothe20162017yemenicholeraepidemic AT thomsonnicholasr genomicinsightsintothe20162017yemenicholeraepidemic AT quilicimarielaure genomicinsightsintothe20162017yemenicholeraepidemic |