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Genomic insights into the 2016-2017 Yemeni cholera epidemic

Yemen is currently experiencing the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported1. We investigated the phylogenetic relationships, pathogenesis, and antimicrobial resistance determina...

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Autores principales: Weill, François-Xavier, Domman, Daryl, Njamkepo, Elisabeth, Almesbahi, Abdullrahman A., Naji, Mona, Nasher, Samar Saeed, Rakesh, Ankur, Assiri, Abdullah M., Sharma, Naresh Chand, Kariuki, Samuel, Pourshafie, Mohammad Reza, Rauzier, Jean, Abubakar, Abdinasir, Carter, Jane Y., Wamala, Joseph F., Seguin, Caroline, Bouchier, Christiane, Malliavin, Thérèse, Bakhshi, Bita, Abulmaali, Hayder H. N., Kumar, Dhirendra, Njoroge, Samuel M., Malik, Mamunur Rahman, Kiiru, John, Luquero, Francisco J., Azman, Andrew S., Ramamurthy, Thandavarayan, Thomson, Nicholas R., Quilici, Marie-Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420076/
https://www.ncbi.nlm.nih.gov/pubmed/30602788
http://dx.doi.org/10.1038/s41586-018-0818-3
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author Weill, François-Xavier
Domman, Daryl
Njamkepo, Elisabeth
Almesbahi, Abdullrahman A.
Naji, Mona
Nasher, Samar Saeed
Rakesh, Ankur
Assiri, Abdullah M.
Sharma, Naresh Chand
Kariuki, Samuel
Pourshafie, Mohammad Reza
Rauzier, Jean
Abubakar, Abdinasir
Carter, Jane Y.
Wamala, Joseph F.
Seguin, Caroline
Bouchier, Christiane
Malliavin, Thérèse
Bakhshi, Bita
Abulmaali, Hayder H. N.
Kumar, Dhirendra
Njoroge, Samuel M.
Malik, Mamunur Rahman
Kiiru, John
Luquero, Francisco J.
Azman, Andrew S.
Ramamurthy, Thandavarayan
Thomson, Nicholas R.
Quilici, Marie-Laure
author_facet Weill, François-Xavier
Domman, Daryl
Njamkepo, Elisabeth
Almesbahi, Abdullrahman A.
Naji, Mona
Nasher, Samar Saeed
Rakesh, Ankur
Assiri, Abdullah M.
Sharma, Naresh Chand
Kariuki, Samuel
Pourshafie, Mohammad Reza
Rauzier, Jean
Abubakar, Abdinasir
Carter, Jane Y.
Wamala, Joseph F.
Seguin, Caroline
Bouchier, Christiane
Malliavin, Thérèse
Bakhshi, Bita
Abulmaali, Hayder H. N.
Kumar, Dhirendra
Njoroge, Samuel M.
Malik, Mamunur Rahman
Kiiru, John
Luquero, Francisco J.
Azman, Andrew S.
Ramamurthy, Thandavarayan
Thomson, Nicholas R.
Quilici, Marie-Laure
author_sort Weill, François-Xavier
collection PubMed
description Yemen is currently experiencing the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported1. We investigated the phylogenetic relationships, pathogenesis, and antimicrobial resistance determinants by sequencing the genomes of Vibrio cholerae isolates from the Yemen epidemic and recent isolates from neighbouring regions. These 116 genomic sequences were placed within the phylogenetic context of a global collection of 1087 seventh pandemic V. cholerae serogroup O1 and O139 biotype El Tor isolates [2–4]. We show that the Yemeni isolates collected during the two epidemiological waves of the epidemic [1], —the first between September 28(th) 2016 and April 23(rd) 2017 (25,839 suspected cases) and the second beginning on April 24(th), 2017 (more than one million suspected cases), — are seventh pandemic V. cholerae O1 El Tor (7PET) serotype Ogawa isolates from a single sublineage. Using genomic approaches, we link the Yemen epidemic to global radiations of pandemic V. cholerae and show that this sublineage originated from South Asia and that it caused outbreaks in East Africa before appearing in Yemen. We also show that the Yemeni isolates are susceptible to several antibiotics commonly used to treat cholera, and to polymyxins, resistance to which is used as a marker of the El Tor biotype.
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spelling pubmed-64200762019-07-02 Genomic insights into the 2016-2017 Yemeni cholera epidemic Weill, François-Xavier Domman, Daryl Njamkepo, Elisabeth Almesbahi, Abdullrahman A. Naji, Mona Nasher, Samar Saeed Rakesh, Ankur Assiri, Abdullah M. Sharma, Naresh Chand Kariuki, Samuel Pourshafie, Mohammad Reza Rauzier, Jean Abubakar, Abdinasir Carter, Jane Y. Wamala, Joseph F. Seguin, Caroline Bouchier, Christiane Malliavin, Thérèse Bakhshi, Bita Abulmaali, Hayder H. N. Kumar, Dhirendra Njoroge, Samuel M. Malik, Mamunur Rahman Kiiru, John Luquero, Francisco J. Azman, Andrew S. Ramamurthy, Thandavarayan Thomson, Nicholas R. Quilici, Marie-Laure Nature Article Yemen is currently experiencing the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported1. We investigated the phylogenetic relationships, pathogenesis, and antimicrobial resistance determinants by sequencing the genomes of Vibrio cholerae isolates from the Yemen epidemic and recent isolates from neighbouring regions. These 116 genomic sequences were placed within the phylogenetic context of a global collection of 1087 seventh pandemic V. cholerae serogroup O1 and O139 biotype El Tor isolates [2–4]. We show that the Yemeni isolates collected during the two epidemiological waves of the epidemic [1], —the first between September 28(th) 2016 and April 23(rd) 2017 (25,839 suspected cases) and the second beginning on April 24(th), 2017 (more than one million suspected cases), — are seventh pandemic V. cholerae O1 El Tor (7PET) serotype Ogawa isolates from a single sublineage. Using genomic approaches, we link the Yemen epidemic to global radiations of pandemic V. cholerae and show that this sublineage originated from South Asia and that it caused outbreaks in East Africa before appearing in Yemen. We also show that the Yemeni isolates are susceptible to several antibiotics commonly used to treat cholera, and to polymyxins, resistance to which is used as a marker of the El Tor biotype. 2019-01-02 2019-01-10 /pmc/articles/PMC6420076/ /pubmed/30602788 http://dx.doi.org/10.1038/s41586-018-0818-3 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Weill, François-Xavier
Domman, Daryl
Njamkepo, Elisabeth
Almesbahi, Abdullrahman A.
Naji, Mona
Nasher, Samar Saeed
Rakesh, Ankur
Assiri, Abdullah M.
Sharma, Naresh Chand
Kariuki, Samuel
Pourshafie, Mohammad Reza
Rauzier, Jean
Abubakar, Abdinasir
Carter, Jane Y.
Wamala, Joseph F.
Seguin, Caroline
Bouchier, Christiane
Malliavin, Thérèse
Bakhshi, Bita
Abulmaali, Hayder H. N.
Kumar, Dhirendra
Njoroge, Samuel M.
Malik, Mamunur Rahman
Kiiru, John
Luquero, Francisco J.
Azman, Andrew S.
Ramamurthy, Thandavarayan
Thomson, Nicholas R.
Quilici, Marie-Laure
Genomic insights into the 2016-2017 Yemeni cholera epidemic
title Genomic insights into the 2016-2017 Yemeni cholera epidemic
title_full Genomic insights into the 2016-2017 Yemeni cholera epidemic
title_fullStr Genomic insights into the 2016-2017 Yemeni cholera epidemic
title_full_unstemmed Genomic insights into the 2016-2017 Yemeni cholera epidemic
title_short Genomic insights into the 2016-2017 Yemeni cholera epidemic
title_sort genomic insights into the 2016-2017 yemeni cholera epidemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420076/
https://www.ncbi.nlm.nih.gov/pubmed/30602788
http://dx.doi.org/10.1038/s41586-018-0818-3
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