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Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis

BACKGROUND: Sucrose allyl ether (SAE) containing hemostatic drugs and a photoinitiator was established to treat mild postpartum hemorrhage or long-term continuous abnormal uterine bleeding in minimally invasive surgery (MIS) using a photopolymerization method. METHODS AND RESULTS: Real-time infrared...

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Autores principales: Huang, Hong, Liu, Houhe, Zhou, Hua, Liang, Zhiling, Song, Dandan, Zhang, Yun, Huang, Wanqiu, Zhao, Xiaotian, Wu, Bo, Ye, Guodong, Huang, Yugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420104/
https://www.ncbi.nlm.nih.gov/pubmed/30880920
http://dx.doi.org/10.2147/DDDT.S180842
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author Huang, Hong
Liu, Houhe
Zhou, Hua
Liang, Zhiling
Song, Dandan
Zhang, Yun
Huang, Wanqiu
Zhao, Xiaotian
Wu, Bo
Ye, Guodong
Huang, Yugang
author_facet Huang, Hong
Liu, Houhe
Zhou, Hua
Liang, Zhiling
Song, Dandan
Zhang, Yun
Huang, Wanqiu
Zhao, Xiaotian
Wu, Bo
Ye, Guodong
Huang, Yugang
author_sort Huang, Hong
collection PubMed
description BACKGROUND: Sucrose allyl ether (SAE) containing hemostatic drugs and a photoinitiator was established to treat mild postpartum hemorrhage or long-term continuous abnormal uterine bleeding in minimally invasive surgery (MIS) using a photopolymerization method. METHODS AND RESULTS: Real-time infrared spectroscopy and rheological experiments showed that the SAE monomer with shear-thinning characteristics could polymerize rapidly into a transparent membrane. Cytotoxicity experiments in vitro showed that this system could elicit a long-term hemostatic effect. Tissue adhesion was also evaluated. The photo-stability of four delivered antifibrinolytic drugs (6-aminocaproic acid, ethylenediaminediacetic acid, tranexamic acid and p-(aminomethyl) benzoic acid) was tested by ultraviolet-photolysis experiments and illustrated by time-dependent density functional theory. Sustained-release experiments revealed that the formed film could be used as a drug carrier. Molecular docking and molecular dynamics were done to investigate the binding mechanism between hemostatic drugs as ligands and the human plasminogen kringle-1 (1HPK) as a target. CONCLUSION: It has been suggested that SAE with tranexamic acid could be a drug-release system of microchannel transport used in MIS. This system could tackle the dilemma of fluidity and adhesion in MIS. The photo-stable tranexamic acid was the most suitable drug according to its satisfactory binding energy, good photo-stability, and sustained release.
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spelling pubmed-64201042019-03-16 Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis Huang, Hong Liu, Houhe Zhou, Hua Liang, Zhiling Song, Dandan Zhang, Yun Huang, Wanqiu Zhao, Xiaotian Wu, Bo Ye, Guodong Huang, Yugang Drug Des Devel Ther Original Research BACKGROUND: Sucrose allyl ether (SAE) containing hemostatic drugs and a photoinitiator was established to treat mild postpartum hemorrhage or long-term continuous abnormal uterine bleeding in minimally invasive surgery (MIS) using a photopolymerization method. METHODS AND RESULTS: Real-time infrared spectroscopy and rheological experiments showed that the SAE monomer with shear-thinning characteristics could polymerize rapidly into a transparent membrane. Cytotoxicity experiments in vitro showed that this system could elicit a long-term hemostatic effect. Tissue adhesion was also evaluated. The photo-stability of four delivered antifibrinolytic drugs (6-aminocaproic acid, ethylenediaminediacetic acid, tranexamic acid and p-(aminomethyl) benzoic acid) was tested by ultraviolet-photolysis experiments and illustrated by time-dependent density functional theory. Sustained-release experiments revealed that the formed film could be used as a drug carrier. Molecular docking and molecular dynamics were done to investigate the binding mechanism between hemostatic drugs as ligands and the human plasminogen kringle-1 (1HPK) as a target. CONCLUSION: It has been suggested that SAE with tranexamic acid could be a drug-release system of microchannel transport used in MIS. This system could tackle the dilemma of fluidity and adhesion in MIS. The photo-stable tranexamic acid was the most suitable drug according to its satisfactory binding energy, good photo-stability, and sustained release. Dove Medical Press 2019-03-12 /pmc/articles/PMC6420104/ /pubmed/30880920 http://dx.doi.org/10.2147/DDDT.S180842 Text en © 2019 Huang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Huang, Hong
Liu, Houhe
Zhou, Hua
Liang, Zhiling
Song, Dandan
Zhang, Yun
Huang, Wanqiu
Zhao, Xiaotian
Wu, Bo
Ye, Guodong
Huang, Yugang
Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
title Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
title_full Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
title_fullStr Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
title_full_unstemmed Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
title_short Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
title_sort drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420104/
https://www.ncbi.nlm.nih.gov/pubmed/30880920
http://dx.doi.org/10.2147/DDDT.S180842
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