Memory CD4(+) T cells are generated in the human fetal intestine

The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO(+) T cells reside in the fetal intestine. Here we combined functional assays with mass cytometry, single-cell RNA-sequencing and high-throughput T cell antigen receptor (TCR) sequencing to characterize the CD4(+) T ce...

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Detalles Bibliográficos
Autores principales: Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin, McLaren, James E., Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F.C.C., Chudakov, Dmitriy M., Price, David A., Lelieveldt, Boudewijn P.F., Koning, Frits
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420108/
https://www.ncbi.nlm.nih.gov/pubmed/30664737
http://dx.doi.org/10.1038/s41590-018-0294-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420108/
https://www.ncbi.nlm.nih.gov/pubmed/30664737
http://dx.doi.org/10.1038/s41590-018-0294-9

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