Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading pathogens.We determined the molecular mechanism underlying the clonal selection and affinity maturation of human B cells expressing protective antibo...

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Detalles Bibliográficos
Autores principales: Imkeller, Katharina, Scally, Stephen W., Bosch, Alexandre, Martí, Gemma Pidelaserra, Costa, Giulia, Triller, Gianna, Murugan, Rajagopal, Renna, Valerio, Jumaa, Hassan, Kremsner, Peter G., Sim, B. Kim Lee, Hoffman, Stephen L., Mordmüller, Benjamin, Levashina, Elena A., Julien, Jean-Philippe, Wardemann, Hedda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420115/
https://www.ncbi.nlm.nih.gov/pubmed/29880723
http://dx.doi.org/10.1126/science.aar5304

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