ApoE attenuates unresolvable inflammation by complex formation with activated C1q

ApoE has been implicated in Alzheimer´s disease, atherosclerosis, and other unresolvable inflammatory conditions but a common mechanism of action remains elusive. We found in ApoE-deficient mice that oxidized lipids activated the classical complement cascade (CCC) resulting in leukocyte infiltration...

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Detalles Bibliográficos
Autores principales: Yin, Changjun, Ackermann, Susanne, Ma, Zhe, Mohanta, Sarajo K., Zhang, Chuankai, Li, Yuanfang, Nietzsche, Sandor, Westermann, Martin, Peng, Li, Hu, Desheng, Bontha, Sai Vineela, Srikakulapu, Prasad, Beer, Michael, Megens, Remco T.A., Steffens, Sabine, Hildner, Markus, Halder, Luke D., Eckstein, Hans-Henning, Pelisek, Jaroslav, Herms, Jochen, Roeber, Sigrun, Arzberger, Thomas, Borodovsky, Anna, Habenicht, Livia, Binder, Christoph J., Weber, Christian, Zipfel, Peter F., Skerka, Christine, Habenicht, Andreas J.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420126/
https://www.ncbi.nlm.nih.gov/pubmed/30692699
http://dx.doi.org/10.1038/s41591-018-0336-8

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