Acute Myeloid Leukemia with t(8;21)(q22;q22) and Trisomy 4: A Rare Occurrence in a Female Child

Acute myeloid leukemia (AML) with balanced translocation t (8;21) is one of the most frequent chromosomal abnormalities and carries a favorable clinical outcome. However, according to a literature review, additional chromosomal aberrations can affect the overall disease prognosis. Trisomy 4 is a rar...

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Detalles Bibliográficos
Autores principales: Kamran, Shawana, Awan, Sara A, Ahmad, Kamran N, Iqbal, Yasir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420323/
https://www.ncbi.nlm.nih.gov/pubmed/30899636
http://dx.doi.org/10.7759/cureus.3885
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author Kamran, Shawana
Awan, Sara A
Ahmad, Kamran N
Iqbal, Yasir
author_facet Kamran, Shawana
Awan, Sara A
Ahmad, Kamran N
Iqbal, Yasir
author_sort Kamran, Shawana
collection PubMed
description Acute myeloid leukemia (AML) with balanced translocation t (8;21) is one of the most frequent chromosomal abnormalities and carries a favorable clinical outcome. However, according to a literature review, additional chromosomal aberrations can affect the overall disease prognosis. Trisomy 4 is a rare numerical abnormality in AML patients with t (8;21), which can be associated with c-KIT gene involvement. In adults, c-KIT mutation carries an unfavorable clinical outcome; however, its incidence and clinical importance in the pediatric population are still under scrutiny. Here, we report a case of AML with t(8;21) and trisomy 4 in an eight-year-old female child and the clinical course of the disease.
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spelling pubmed-64203232019-03-21 Acute Myeloid Leukemia with t(8;21)(q22;q22) and Trisomy 4: A Rare Occurrence in a Female Child Kamran, Shawana Awan, Sara A Ahmad, Kamran N Iqbal, Yasir Cureus Genetics Acute myeloid leukemia (AML) with balanced translocation t (8;21) is one of the most frequent chromosomal abnormalities and carries a favorable clinical outcome. However, according to a literature review, additional chromosomal aberrations can affect the overall disease prognosis. Trisomy 4 is a rare numerical abnormality in AML patients with t (8;21), which can be associated with c-KIT gene involvement. In adults, c-KIT mutation carries an unfavorable clinical outcome; however, its incidence and clinical importance in the pediatric population are still under scrutiny. Here, we report a case of AML with t(8;21) and trisomy 4 in an eight-year-old female child and the clinical course of the disease. Cureus 2019-01-14 /pmc/articles/PMC6420323/ /pubmed/30899636 http://dx.doi.org/10.7759/cureus.3885 Text en Copyright © 2019, Kamran et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Kamran, Shawana
Awan, Sara A
Ahmad, Kamran N
Iqbal, Yasir
Acute Myeloid Leukemia with t(8;21)(q22;q22) and Trisomy 4: A Rare Occurrence in a Female Child
title Acute Myeloid Leukemia with t(8;21)(q22;q22) and Trisomy 4: A Rare Occurrence in a Female Child
title_full Acute Myeloid Leukemia with t(8;21)(q22;q22) and Trisomy 4: A Rare Occurrence in a Female Child
title_fullStr Acute Myeloid Leukemia with t(8;21)(q22;q22) and Trisomy 4: A Rare Occurrence in a Female Child
title_full_unstemmed Acute Myeloid Leukemia with t(8;21)(q22;q22) and Trisomy 4: A Rare Occurrence in a Female Child
title_short Acute Myeloid Leukemia with t(8;21)(q22;q22) and Trisomy 4: A Rare Occurrence in a Female Child
title_sort acute myeloid leukemia with t(8;21)(q22;q22) and trisomy 4: a rare occurrence in a female child
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420323/
https://www.ncbi.nlm.nih.gov/pubmed/30899636
http://dx.doi.org/10.7759/cureus.3885
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