Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial

Cohabiting children may share components of their intestinal microbiome. We evaluated whether receipt of azithromycin in one sibling confers changes to the intestinal microbiome in an untreated sibling compared with placebo in a randomized controlled trial. We found no evidence of an indirect effect...

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Autores principales: Oldenburg, Catherine E, Sié, Ali, Coulibaly, Boubacar, Ouermi, Lucienne, Dah, Clarisse, Tapsoba, Charlemagne, Bärnighausen, Till, Lebas, Elodie, Arzika, Ahmed M, Cummings, Susie, Zhong, Lina, Lietman, Thomas M, Keenan, Jeremy D, Doan, Thuy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420410/
https://www.ncbi.nlm.nih.gov/pubmed/30895203
http://dx.doi.org/10.1093/ofid/ofz061
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author Oldenburg, Catherine E
Sié, Ali
Coulibaly, Boubacar
Ouermi, Lucienne
Dah, Clarisse
Tapsoba, Charlemagne
Bärnighausen, Till
Lebas, Elodie
Arzika, Ahmed M
Cummings, Susie
Zhong, Lina
Lietman, Thomas M
Keenan, Jeremy D
Doan, Thuy
author_facet Oldenburg, Catherine E
Sié, Ali
Coulibaly, Boubacar
Ouermi, Lucienne
Dah, Clarisse
Tapsoba, Charlemagne
Bärnighausen, Till
Lebas, Elodie
Arzika, Ahmed M
Cummings, Susie
Zhong, Lina
Lietman, Thomas M
Keenan, Jeremy D
Doan, Thuy
author_sort Oldenburg, Catherine E
collection PubMed
description Cohabiting children may share components of their intestinal microbiome. We evaluated whether receipt of azithromycin in one sibling confers changes to the intestinal microbiome in an untreated sibling compared with placebo in a randomized controlled trial. We found no evidence of an indirect effect of antibiotic use in cohabiting children. Clinical Trials Registrations: NCT03187834.
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spelling pubmed-64204102019-03-20 Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial Oldenburg, Catherine E Sié, Ali Coulibaly, Boubacar Ouermi, Lucienne Dah, Clarisse Tapsoba, Charlemagne Bärnighausen, Till Lebas, Elodie Arzika, Ahmed M Cummings, Susie Zhong, Lina Lietman, Thomas M Keenan, Jeremy D Doan, Thuy Open Forum Infect Dis Brief Report Cohabiting children may share components of their intestinal microbiome. We evaluated whether receipt of azithromycin in one sibling confers changes to the intestinal microbiome in an untreated sibling compared with placebo in a randomized controlled trial. We found no evidence of an indirect effect of antibiotic use in cohabiting children. Clinical Trials Registrations: NCT03187834. Oxford University Press 2019-02-06 /pmc/articles/PMC6420410/ /pubmed/30895203 http://dx.doi.org/10.1093/ofid/ofz061 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Oldenburg, Catherine E
Sié, Ali
Coulibaly, Boubacar
Ouermi, Lucienne
Dah, Clarisse
Tapsoba, Charlemagne
Bärnighausen, Till
Lebas, Elodie
Arzika, Ahmed M
Cummings, Susie
Zhong, Lina
Lietman, Thomas M
Keenan, Jeremy D
Doan, Thuy
Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial
title Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial
title_full Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial
title_fullStr Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial
title_full_unstemmed Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial
title_short Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial
title_sort indirect effect of azithromycin use on the intestinal microbiome diversity of untreated children: a randomized trial
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420410/
https://www.ncbi.nlm.nih.gov/pubmed/30895203
http://dx.doi.org/10.1093/ofid/ofz061
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