NMDA Receptor Dependent Long-term Potentiation in Chronic Pain

Since the discovery of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) in the hippocampus, many studies have demonstrated that NMDAR dependent LTP exists throughout central synapses, including those involved in sensory transmission and perception. NMDAR LTP has been reported in spinal c...

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Detalles Bibliográficos
Autores principales: Li, Xu-Hui, Miao, Hui-Hui, Zhuo, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420414/
https://www.ncbi.nlm.nih.gov/pubmed/30109556
http://dx.doi.org/10.1007/s11064-018-2614-8
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author Li, Xu-Hui
Miao, Hui-Hui
Zhuo, Min
author_facet Li, Xu-Hui
Miao, Hui-Hui
Zhuo, Min
author_sort Li, Xu-Hui
collection PubMed
description Since the discovery of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) in the hippocampus, many studies have demonstrated that NMDAR dependent LTP exists throughout central synapses, including those involved in sensory transmission and perception. NMDAR LTP has been reported in spinal cord dorsal horn synapses, anterior cingulate cortex and insular cortex. Behavioral, genetic and pharmacological studies show that inhibiting or reducing NMDAR LTP produced analgesic effects in animal models of chronic pain. Investigation of signalling mechanisms for NMDAR LTP may provide novel targets for future treatment of chronic pain.
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spelling pubmed-64204142019-04-03 NMDA Receptor Dependent Long-term Potentiation in Chronic Pain Li, Xu-Hui Miao, Hui-Hui Zhuo, Min Neurochem Res Original Paper Since the discovery of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) in the hippocampus, many studies have demonstrated that NMDAR dependent LTP exists throughout central synapses, including those involved in sensory transmission and perception. NMDAR LTP has been reported in spinal cord dorsal horn synapses, anterior cingulate cortex and insular cortex. Behavioral, genetic and pharmacological studies show that inhibiting or reducing NMDAR LTP produced analgesic effects in animal models of chronic pain. Investigation of signalling mechanisms for NMDAR LTP may provide novel targets for future treatment of chronic pain. Springer US 2018-08-14 2019 /pmc/articles/PMC6420414/ /pubmed/30109556 http://dx.doi.org/10.1007/s11064-018-2614-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Li, Xu-Hui
Miao, Hui-Hui
Zhuo, Min
NMDA Receptor Dependent Long-term Potentiation in Chronic Pain
title NMDA Receptor Dependent Long-term Potentiation in Chronic Pain
title_full NMDA Receptor Dependent Long-term Potentiation in Chronic Pain
title_fullStr NMDA Receptor Dependent Long-term Potentiation in Chronic Pain
title_full_unstemmed NMDA Receptor Dependent Long-term Potentiation in Chronic Pain
title_short NMDA Receptor Dependent Long-term Potentiation in Chronic Pain
title_sort nmda receptor dependent long-term potentiation in chronic pain
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420414/
https://www.ncbi.nlm.nih.gov/pubmed/30109556
http://dx.doi.org/10.1007/s11064-018-2614-8
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