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Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy

The treatment of patients with chronic hepatitis C virus (HCV) infection has changed tremendously over the past 2 years, with an increasing variety of all-oral direct-acting antiviral (DAA) treatment regimens available for different HCV genotypes and distinct clinical settings. These treatments have...

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Autores principales: Urbanowicz, Arkadiusz, Zagożdżon, Radosław, Ciszek, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420452/
https://www.ncbi.nlm.nih.gov/pubmed/30443787
http://dx.doi.org/10.1007/s00005-018-0532-8
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author Urbanowicz, Arkadiusz
Zagożdżon, Radosław
Ciszek, Michał
author_facet Urbanowicz, Arkadiusz
Zagożdżon, Radosław
Ciszek, Michał
author_sort Urbanowicz, Arkadiusz
collection PubMed
description The treatment of patients with chronic hepatitis C virus (HCV) infection has changed tremendously over the past 2 years, with an increasing variety of all-oral direct-acting antiviral (DAA) treatment regimens available for different HCV genotypes and distinct clinical settings. These treatments have significantly improved safety in patients with advanced liver disease compared with interferon (IFN)-based regimens. HCV modifies the human immune system to escape immunosurveillance via several mechanisms. One of the basic mechanisms of HCV is the ability to “switch” the immune response by reducing the activity of cells responsible for the elimination of virus-infected cells. IFN-free DAA treatment regimens provide a unique opportunity to assess the effect of HCV elimination on the immune system. Abrupt changes in the immune system can in some cases be responsible for two alarming processes: viral reactivation in patients with chronic hepatitis B and recurrence of hepatocellular carcinoma in patients with previous successful cancer treatment.
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spelling pubmed-64204522019-04-08 Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy Urbanowicz, Arkadiusz Zagożdżon, Radosław Ciszek, Michał Arch Immunol Ther Exp (Warsz) Review The treatment of patients with chronic hepatitis C virus (HCV) infection has changed tremendously over the past 2 years, with an increasing variety of all-oral direct-acting antiviral (DAA) treatment regimens available for different HCV genotypes and distinct clinical settings. These treatments have significantly improved safety in patients with advanced liver disease compared with interferon (IFN)-based regimens. HCV modifies the human immune system to escape immunosurveillance via several mechanisms. One of the basic mechanisms of HCV is the ability to “switch” the immune response by reducing the activity of cells responsible for the elimination of virus-infected cells. IFN-free DAA treatment regimens provide a unique opportunity to assess the effect of HCV elimination on the immune system. Abrupt changes in the immune system can in some cases be responsible for two alarming processes: viral reactivation in patients with chronic hepatitis B and recurrence of hepatocellular carcinoma in patients with previous successful cancer treatment. Springer International Publishing 2018-11-15 2019 /pmc/articles/PMC6420452/ /pubmed/30443787 http://dx.doi.org/10.1007/s00005-018-0532-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Urbanowicz, Arkadiusz
Zagożdżon, Radosław
Ciszek, Michał
Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy
title Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy
title_full Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy
title_fullStr Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy
title_full_unstemmed Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy
title_short Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy
title_sort modulation of the immune system in chronic hepatitis c and during antiviral interferon-free therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420452/
https://www.ncbi.nlm.nih.gov/pubmed/30443787
http://dx.doi.org/10.1007/s00005-018-0532-8
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