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Gradients of connectivity distance in the cerebral cortex of the macaque monkey

Cortical connectivity conforms to a series of organizing principles that are common across species. Spatial proximity, similar cortical type, and similar connectional profile all constitute factors for determining the connectivity between cortical regions. We previously demonstrated another principl...

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Autores principales: Oligschläger, Sabine, Xu, Ting, Baczkowski, Blazej M., Falkiewicz, Marcel, Falchier, Arnaud, Linn, Gary, Margulies, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420469/
https://www.ncbi.nlm.nih.gov/pubmed/30547311
http://dx.doi.org/10.1007/s00429-018-1811-1
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author Oligschläger, Sabine
Xu, Ting
Baczkowski, Blazej M.
Falkiewicz, Marcel
Falchier, Arnaud
Linn, Gary
Margulies, Daniel S.
author_facet Oligschläger, Sabine
Xu, Ting
Baczkowski, Blazej M.
Falkiewicz, Marcel
Falchier, Arnaud
Linn, Gary
Margulies, Daniel S.
author_sort Oligschläger, Sabine
collection PubMed
description Cortical connectivity conforms to a series of organizing principles that are common across species. Spatial proximity, similar cortical type, and similar connectional profile all constitute factors for determining the connectivity between cortical regions. We previously demonstrated another principle of connectivity that is closely related to the spatial layout of the cerebral cortex. Using functional connectivity from resting-state fMRI in the human cortex, we found that the further a region is located from primary cortex, the more distant are its functional connections with the other areas of the cortex. However, it remains unknown whether this relationship between cortical layout and connectivity extends to other primate species. Here, we investigated this relationship using both resting-state functional connectivity as well as gold-standard tract-tracing connectivity in the macaque monkey cortex. For both measures of connectivity, we found a gradient of connectivity distance extending between primary and frontoparietal regions. In the human cortex, the further a region is located from primary areas, the stronger its connections to distant portions of the cortex, with connectivity distance highest in frontal and parietal regions. The similarity between the human and macaque findings provides evidence for a phylogenetically conserved relationship between the spatial layout of cortical areas and connectivity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00429-018-1811-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-64204692019-04-03 Gradients of connectivity distance in the cerebral cortex of the macaque monkey Oligschläger, Sabine Xu, Ting Baczkowski, Blazej M. Falkiewicz, Marcel Falchier, Arnaud Linn, Gary Margulies, Daniel S. Brain Struct Funct Original Article Cortical connectivity conforms to a series of organizing principles that are common across species. Spatial proximity, similar cortical type, and similar connectional profile all constitute factors for determining the connectivity between cortical regions. We previously demonstrated another principle of connectivity that is closely related to the spatial layout of the cerebral cortex. Using functional connectivity from resting-state fMRI in the human cortex, we found that the further a region is located from primary cortex, the more distant are its functional connections with the other areas of the cortex. However, it remains unknown whether this relationship between cortical layout and connectivity extends to other primate species. Here, we investigated this relationship using both resting-state functional connectivity as well as gold-standard tract-tracing connectivity in the macaque monkey cortex. For both measures of connectivity, we found a gradient of connectivity distance extending between primary and frontoparietal regions. In the human cortex, the further a region is located from primary areas, the stronger its connections to distant portions of the cortex, with connectivity distance highest in frontal and parietal regions. The similarity between the human and macaque findings provides evidence for a phylogenetically conserved relationship between the spatial layout of cortical areas and connectivity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00429-018-1811-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-12-13 2019 /pmc/articles/PMC6420469/ /pubmed/30547311 http://dx.doi.org/10.1007/s00429-018-1811-1 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Oligschläger, Sabine
Xu, Ting
Baczkowski, Blazej M.
Falkiewicz, Marcel
Falchier, Arnaud
Linn, Gary
Margulies, Daniel S.
Gradients of connectivity distance in the cerebral cortex of the macaque monkey
title Gradients of connectivity distance in the cerebral cortex of the macaque monkey
title_full Gradients of connectivity distance in the cerebral cortex of the macaque monkey
title_fullStr Gradients of connectivity distance in the cerebral cortex of the macaque monkey
title_full_unstemmed Gradients of connectivity distance in the cerebral cortex of the macaque monkey
title_short Gradients of connectivity distance in the cerebral cortex of the macaque monkey
title_sort gradients of connectivity distance in the cerebral cortex of the macaque monkey
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420469/
https://www.ncbi.nlm.nih.gov/pubmed/30547311
http://dx.doi.org/10.1007/s00429-018-1811-1
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