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Gradients of connectivity distance in the cerebral cortex of the macaque monkey
Cortical connectivity conforms to a series of organizing principles that are common across species. Spatial proximity, similar cortical type, and similar connectional profile all constitute factors for determining the connectivity between cortical regions. We previously demonstrated another principl...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420469/ https://www.ncbi.nlm.nih.gov/pubmed/30547311 http://dx.doi.org/10.1007/s00429-018-1811-1 |
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author | Oligschläger, Sabine Xu, Ting Baczkowski, Blazej M. Falkiewicz, Marcel Falchier, Arnaud Linn, Gary Margulies, Daniel S. |
author_facet | Oligschläger, Sabine Xu, Ting Baczkowski, Blazej M. Falkiewicz, Marcel Falchier, Arnaud Linn, Gary Margulies, Daniel S. |
author_sort | Oligschläger, Sabine |
collection | PubMed |
description | Cortical connectivity conforms to a series of organizing principles that are common across species. Spatial proximity, similar cortical type, and similar connectional profile all constitute factors for determining the connectivity between cortical regions. We previously demonstrated another principle of connectivity that is closely related to the spatial layout of the cerebral cortex. Using functional connectivity from resting-state fMRI in the human cortex, we found that the further a region is located from primary cortex, the more distant are its functional connections with the other areas of the cortex. However, it remains unknown whether this relationship between cortical layout and connectivity extends to other primate species. Here, we investigated this relationship using both resting-state functional connectivity as well as gold-standard tract-tracing connectivity in the macaque monkey cortex. For both measures of connectivity, we found a gradient of connectivity distance extending between primary and frontoparietal regions. In the human cortex, the further a region is located from primary areas, the stronger its connections to distant portions of the cortex, with connectivity distance highest in frontal and parietal regions. The similarity between the human and macaque findings provides evidence for a phylogenetically conserved relationship between the spatial layout of cortical areas and connectivity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00429-018-1811-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6420469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-64204692019-04-03 Gradients of connectivity distance in the cerebral cortex of the macaque monkey Oligschläger, Sabine Xu, Ting Baczkowski, Blazej M. Falkiewicz, Marcel Falchier, Arnaud Linn, Gary Margulies, Daniel S. Brain Struct Funct Original Article Cortical connectivity conforms to a series of organizing principles that are common across species. Spatial proximity, similar cortical type, and similar connectional profile all constitute factors for determining the connectivity between cortical regions. We previously demonstrated another principle of connectivity that is closely related to the spatial layout of the cerebral cortex. Using functional connectivity from resting-state fMRI in the human cortex, we found that the further a region is located from primary cortex, the more distant are its functional connections with the other areas of the cortex. However, it remains unknown whether this relationship between cortical layout and connectivity extends to other primate species. Here, we investigated this relationship using both resting-state functional connectivity as well as gold-standard tract-tracing connectivity in the macaque monkey cortex. For both measures of connectivity, we found a gradient of connectivity distance extending between primary and frontoparietal regions. In the human cortex, the further a region is located from primary areas, the stronger its connections to distant portions of the cortex, with connectivity distance highest in frontal and parietal regions. The similarity between the human and macaque findings provides evidence for a phylogenetically conserved relationship between the spatial layout of cortical areas and connectivity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00429-018-1811-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-12-13 2019 /pmc/articles/PMC6420469/ /pubmed/30547311 http://dx.doi.org/10.1007/s00429-018-1811-1 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Oligschläger, Sabine Xu, Ting Baczkowski, Blazej M. Falkiewicz, Marcel Falchier, Arnaud Linn, Gary Margulies, Daniel S. Gradients of connectivity distance in the cerebral cortex of the macaque monkey |
title | Gradients of connectivity distance in the cerebral cortex of the macaque monkey |
title_full | Gradients of connectivity distance in the cerebral cortex of the macaque monkey |
title_fullStr | Gradients of connectivity distance in the cerebral cortex of the macaque monkey |
title_full_unstemmed | Gradients of connectivity distance in the cerebral cortex of the macaque monkey |
title_short | Gradients of connectivity distance in the cerebral cortex of the macaque monkey |
title_sort | gradients of connectivity distance in the cerebral cortex of the macaque monkey |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420469/ https://www.ncbi.nlm.nih.gov/pubmed/30547311 http://dx.doi.org/10.1007/s00429-018-1811-1 |
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