Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes

Neurodegenerative diseases such as Alzheimer’s disease are characterized by the progressive spreading and accumulation of hyper-phosphorylated tau protein in the brain. Anti-tau antibodies have been shown to reduce tau pathology in in vivo models and antibody-mediated clearance of tau exerted by mic...

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Detalles Bibliográficos
Autores principales: Andersson, Christian Rungsted, Falsig, Jeppe, Stavenhagen, Jeffrey B., Christensen, Søren, Kartberg, Fredrik, Rosenqvist, Nina, Finsen, Bente, Pedersen, Jan Torleif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420568/
https://www.ncbi.nlm.nih.gov/pubmed/30874605
http://dx.doi.org/10.1038/s41598-019-41105-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420568/
https://www.ncbi.nlm.nih.gov/pubmed/30874605
http://dx.doi.org/10.1038/s41598-019-41105-4

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