β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma

Hepatocellular carcinoma (HCC), a common liver malignancy worldwide, has high morbidity and mortality. β-Thujaplicin, a tropolone derivative, has been used in some health-care products and clinical adjuvant drugs, but its use for HCC is unknown. In this study, we found that β-Thujaplicin inhibits th...

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Detalles Bibliográficos
Autores principales: Zhang, Guangya, He, Jiangping, Ye, Xiaofei, Zhu, Jing, Hu, Xi, Shen, Minyan, Ma, Yuru, Mao, Ziming, Song, Huaidong, Chen, Fengling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420571/
https://www.ncbi.nlm.nih.gov/pubmed/30874538
http://dx.doi.org/10.1038/s41419-019-1492-6

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