Promoting healthspan and lifespan with caloric restriction in primates

Recent data confirmed the efficiency of caloric restriction for promoting both healthspan and lifespan in primates, but also revealed potential adverse effects at the central level. This paper proposes perspectives and future directions to counterbalance potential adverse effects. Efforts should be...

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Detalles Bibliográficos
Autores principales: Pifferi, Fabien, Terrien, Jérémy, Perret, Martine, Epelbaum, Jacques, Blanc, Stéphane, Picq, Jean-Luc, Dhenain, Marc, Aujard, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420603/
https://www.ncbi.nlm.nih.gov/pubmed/30911682
http://dx.doi.org/10.1038/s42003-019-0348-z
Descripción
Sumario:Recent data confirmed the efficiency of caloric restriction for promoting both healthspan and lifespan in primates, but also revealed potential adverse effects at the central level. This paper proposes perspectives and future directions to counterbalance potential adverse effects. Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects.

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