Promoting healthspan and lifespan with caloric restriction in primates

Recent data confirmed the efficiency of caloric restriction for promoting both healthspan and lifespan in primates, but also revealed potential adverse effects at the central level. This paper proposes perspectives and future directions to counterbalance potential adverse effects. Efforts should be...

Descripción completa

Detalles Bibliográficos
Autores principales: Pifferi, Fabien, Terrien, Jérémy, Perret, Martine, Epelbaum, Jacques, Blanc, Stéphane, Picq, Jean-Luc, Dhenain, Marc, Aujard, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420603/
https://www.ncbi.nlm.nih.gov/pubmed/30911682
http://dx.doi.org/10.1038/s42003-019-0348-z
_version_ 1783404107200987136
author Pifferi, Fabien
Terrien, Jérémy
Perret, Martine
Epelbaum, Jacques
Blanc, Stéphane
Picq, Jean-Luc
Dhenain, Marc
Aujard, Fabienne
author_facet Pifferi, Fabien
Terrien, Jérémy
Perret, Martine
Epelbaum, Jacques
Blanc, Stéphane
Picq, Jean-Luc
Dhenain, Marc
Aujard, Fabienne
author_sort Pifferi, Fabien
collection PubMed
description Recent data confirmed the efficiency of caloric restriction for promoting both healthspan and lifespan in primates, but also revealed potential adverse effects at the central level. This paper proposes perspectives and future directions to counterbalance potential adverse effects. Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects.
format Online
Article
Text
id pubmed-6420603
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-64206032019-03-25 Promoting healthspan and lifespan with caloric restriction in primates Pifferi, Fabien Terrien, Jérémy Perret, Martine Epelbaum, Jacques Blanc, Stéphane Picq, Jean-Luc Dhenain, Marc Aujard, Fabienne Commun Biol Comment Recent data confirmed the efficiency of caloric restriction for promoting both healthspan and lifespan in primates, but also revealed potential adverse effects at the central level. This paper proposes perspectives and future directions to counterbalance potential adverse effects. Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects. Nature Publishing Group UK 2019-03-15 /pmc/articles/PMC6420603/ /pubmed/30911682 http://dx.doi.org/10.1038/s42003-019-0348-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Pifferi, Fabien
Terrien, Jérémy
Perret, Martine
Epelbaum, Jacques
Blanc, Stéphane
Picq, Jean-Luc
Dhenain, Marc
Aujard, Fabienne
Promoting healthspan and lifespan with caloric restriction in primates
title Promoting healthspan and lifespan with caloric restriction in primates
title_full Promoting healthspan and lifespan with caloric restriction in primates
title_fullStr Promoting healthspan and lifespan with caloric restriction in primates
title_full_unstemmed Promoting healthspan and lifespan with caloric restriction in primates
title_short Promoting healthspan and lifespan with caloric restriction in primates
title_sort promoting healthspan and lifespan with caloric restriction in primates
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420603/
https://www.ncbi.nlm.nih.gov/pubmed/30911682
http://dx.doi.org/10.1038/s42003-019-0348-z
work_keys_str_mv AT pifferifabien promotinghealthspanandlifespanwithcaloricrestrictioninprimates
AT terrienjeremy promotinghealthspanandlifespanwithcaloricrestrictioninprimates
AT perretmartine promotinghealthspanandlifespanwithcaloricrestrictioninprimates
AT epelbaumjacques promotinghealthspanandlifespanwithcaloricrestrictioninprimates
AT blancstephane promotinghealthspanandlifespanwithcaloricrestrictioninprimates
AT picqjeanluc promotinghealthspanandlifespanwithcaloricrestrictioninprimates
AT dhenainmarc promotinghealthspanandlifespanwithcaloricrestrictioninprimates
AT aujardfabienne promotinghealthspanandlifespanwithcaloricrestrictioninprimates

Ejemplares similares