Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)

Natural killer T cell lymphoma (NKTL) is an aggressive disease with very poor treatment outcomes in the advanced stages. With chemotherapy, initial response rates to treatment are high but responses are short lived. A better understanding of the complex molecular pathogenesis of this disease is esse...

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Detalles Bibliográficos
Autores principales: Somasundaram, Nagavalli, Lim, Jing Quan, Ong, Choon Kiat, Lim, Soon Thye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420729/
https://www.ncbi.nlm.nih.gov/pubmed/30876435
http://dx.doi.org/10.1186/s13045-019-0717-6
Descripción
Sumario:Natural killer T cell lymphoma (NKTL) is an aggressive disease with very poor treatment outcomes in the advanced stages. With chemotherapy, initial response rates to treatment are high but responses are short lived. A better understanding of the complex molecular pathogenesis of this disease is essential in order to design and develop better therapeutics with improved efficacy. This review aims to summarise the key pathogenic mechanisms in NKTL which may have significant prognostic and therapeutic implications.

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