Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)

Natural killer T cell lymphoma (NKTL) is an aggressive disease with very poor treatment outcomes in the advanced stages. With chemotherapy, initial response rates to treatment are high but responses are short lived. A better understanding of the complex molecular pathogenesis of this disease is esse...

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Autores principales: Somasundaram, Nagavalli, Lim, Jing Quan, Ong, Choon Kiat, Lim, Soon Thye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420729/
https://www.ncbi.nlm.nih.gov/pubmed/30876435
http://dx.doi.org/10.1186/s13045-019-0717-6
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author Somasundaram, Nagavalli
Lim, Jing Quan
Ong, Choon Kiat
Lim, Soon Thye
author_facet Somasundaram, Nagavalli
Lim, Jing Quan
Ong, Choon Kiat
Lim, Soon Thye
author_sort Somasundaram, Nagavalli
collection PubMed
description Natural killer T cell lymphoma (NKTL) is an aggressive disease with very poor treatment outcomes in the advanced stages. With chemotherapy, initial response rates to treatment are high but responses are short lived. A better understanding of the complex molecular pathogenesis of this disease is essential in order to design and develop better therapeutics with improved efficacy. This review aims to summarise the key pathogenic mechanisms in NKTL which may have significant prognostic and therapeutic implications.
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spelling pubmed-64207292019-03-28 Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL) Somasundaram, Nagavalli Lim, Jing Quan Ong, Choon Kiat Lim, Soon Thye J Hematol Oncol Review Natural killer T cell lymphoma (NKTL) is an aggressive disease with very poor treatment outcomes in the advanced stages. With chemotherapy, initial response rates to treatment are high but responses are short lived. A better understanding of the complex molecular pathogenesis of this disease is essential in order to design and develop better therapeutics with improved efficacy. This review aims to summarise the key pathogenic mechanisms in NKTL which may have significant prognostic and therapeutic implications. BioMed Central 2019-03-15 /pmc/articles/PMC6420729/ /pubmed/30876435 http://dx.doi.org/10.1186/s13045-019-0717-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Somasundaram, Nagavalli
Lim, Jing Quan
Ong, Choon Kiat
Lim, Soon Thye
Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
title Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
title_full Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
title_fullStr Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
title_full_unstemmed Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
title_short Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
title_sort pathogenesis and biomarkers of natural killer t cell lymphoma (nktl)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420729/
https://www.ncbi.nlm.nih.gov/pubmed/30876435
http://dx.doi.org/10.1186/s13045-019-0717-6
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