Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis

EWS/FLI is the pathognomic fusion oncoprotein that drives Ewing sarcoma. The amino-terminal EWS portion coordinates transcriptional regulation and the carboxy-terminal FLI portion contains an ETS DNA-binding domain. EWS/FLI acts as an aberrant transcription factor, orchestrating a complex mix of gen...

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Detalles Bibliográficos
Autores principales: Theisen, Emily R., Miller, Kyle R., Showpnil, Iftekhar A., Taslim, Cenny, Pishas, Kathleen I., Lessnick, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420793/
https://www.ncbi.nlm.nih.gov/pubmed/30899417
http://dx.doi.org/10.18632/genesandcancer.188

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