Dimensional Analysis of CD44(High) CD24(Low) and Ki67 in Triple Negative Breast Cancer

AIM: To study the dimensional analysis CD44(high) CD24(low) and Ki67 in triple negative breast cancer (TNBC). METHODS: This cross-sectional study was performed on patients with breast cancer in Haji Adam Malik Hospital Medan from 2013 to 2016 to determine the frequency and pathologic features of TNB...

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Detalles Bibliográficos
Autores principales: Tan, Betty, Kanoko, Mpu, Tan, Gino, Bachtiar, Adang, Munir, Delfitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420956/
https://www.ncbi.nlm.nih.gov/pubmed/30894906
http://dx.doi.org/10.3889/oamjms.2019.182
Descripción
Sumario:AIM: To study the dimensional analysis CD44(high) CD24(low) and Ki67 in triple negative breast cancer (TNBC). METHODS: This cross-sectional study was performed on patients with breast cancer in Haji Adam Malik Hospital Medan from 2013 to 2016 to determine the frequency and pathologic features of TNBC by immunohistochemistry stained. RESULTS: By using immunohistochemistry staining panel of CD44, CD24, Twist, Claudin 7, CK5, CK8/18, EMA, E-Cadherin, Ki-67, a total 67 breast tumour samples with TNBC were classified as 9 stem-cells like 1 basal, 22 baso-luminal, and 23 luminal subtypes CONCLUSION: By using immunohistochemical staining panel, TNBC can be differentiated into stem cells like basal, baso-luminal and luminal subtypes. Didifferentiation and EMT can produce heterogeneity in TNBC subtypes and this will affect in handling TNBC. Stemness in stem cells- like subtypes are resistant to therapy. Therefore, TNBC needs special attention in order to assist in more optimal handling.

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