Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine

Gemcitabine (2′, 2′-difluorodeoxycytidine; dFdC) is a deoxycytidine analog and is used primarily against pancreatic cancer. The cytotoxicity of gemcitabine is due to the inhibition of DNA replication. However, a mechanism of removal of the incorporated dFdC is largely unknown. In this report, we dis...

Descripción completa

Detalles Bibliográficos
Autores principales: George, Joseph W., Bessho, Mika, Bessho, Tadayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421022/
https://www.ncbi.nlm.nih.gov/pubmed/30941207
http://dx.doi.org/10.1155/2019/6357609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421022/
https://www.ncbi.nlm.nih.gov/pubmed/30941207
http://dx.doi.org/10.1155/2019/6357609

Ejemplares similares