Cargando…

Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway

For gastrulation to occur in human embryos, a mechanism that simultaneously regulates many different processes, such as cell differentiation, proliferation, migration, and invasion, is required to consistently and effectively create a human being during embryonic morphogenesis. The striking similari...

Descripción completa

Detalles Bibliográficos
Autores principales: Cofre, Jaime, Saalfeld, Kay, Abdelhay, Eliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421044/
https://www.ncbi.nlm.nih.gov/pubmed/30940992
http://dx.doi.org/10.1155/2019/4714781
_version_ 1783404184583798784
author Cofre, Jaime
Saalfeld, Kay
Abdelhay, Eliana
author_facet Cofre, Jaime
Saalfeld, Kay
Abdelhay, Eliana
author_sort Cofre, Jaime
collection PubMed
description For gastrulation to occur in human embryos, a mechanism that simultaneously regulates many different processes, such as cell differentiation, proliferation, migration, and invasion, is required to consistently and effectively create a human being during embryonic morphogenesis. The striking similarities in the processes of cancer and gastrulation have prompted speculation regarding the developmental pathways involved in their regulation. One of the fundamental requirements for the developmental pathways in gastrulation and cancer is the ability to respond to environmental stimuli, and it has been proposed that the Kaiso and noncanonical Wnt pathways participate in the mechanisms regulating these developmental pathways. In particular, these pathways might also explain the notable differences in invasive capacity between cancers of endodermal and mesodermal origins and cancers of ectodermal origin. Nevertheless, the available information indicates that cancer is an abnormal state of adult human cells in which developmental pathways are reactivated in inappropriate temporal and spatial contexts.
format Online
Article
Text
id pubmed-6421044
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-64210442019-04-02 Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway Cofre, Jaime Saalfeld, Kay Abdelhay, Eliana ScientificWorldJournal Review Article For gastrulation to occur in human embryos, a mechanism that simultaneously regulates many different processes, such as cell differentiation, proliferation, migration, and invasion, is required to consistently and effectively create a human being during embryonic morphogenesis. The striking similarities in the processes of cancer and gastrulation have prompted speculation regarding the developmental pathways involved in their regulation. One of the fundamental requirements for the developmental pathways in gastrulation and cancer is the ability to respond to environmental stimuli, and it has been proposed that the Kaiso and noncanonical Wnt pathways participate in the mechanisms regulating these developmental pathways. In particular, these pathways might also explain the notable differences in invasive capacity between cancers of endodermal and mesodermal origins and cancers of ectodermal origin. Nevertheless, the available information indicates that cancer is an abnormal state of adult human cells in which developmental pathways are reactivated in inappropriate temporal and spatial contexts. Hindawi 2019-03-03 /pmc/articles/PMC6421044/ /pubmed/30940992 http://dx.doi.org/10.1155/2019/4714781 Text en Copyright © 2019 Jaime Cofre et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cofre, Jaime
Saalfeld, Kay
Abdelhay, Eliana
Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway
title Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway
title_full Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway
title_fullStr Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway
title_full_unstemmed Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway
title_short Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway
title_sort cancer as an embryological phenomenon and its developmental pathways: a hypothesis regarding the contribution of the noncanonical wnt pathway
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421044/
https://www.ncbi.nlm.nih.gov/pubmed/30940992
http://dx.doi.org/10.1155/2019/4714781
work_keys_str_mv AT cofrejaime cancerasanembryologicalphenomenonanditsdevelopmentalpathwaysahypothesisregardingthecontributionofthenoncanonicalwntpathway
AT saalfeldkay cancerasanembryologicalphenomenonanditsdevelopmentalpathwaysahypothesisregardingthecontributionofthenoncanonicalwntpathway
AT abdelhayeliana cancerasanembryologicalphenomenonanditsdevelopmentalpathwaysahypothesisregardingthecontributionofthenoncanonicalwntpathway