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Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years
In 1982, we reported a case of retroperitoneal fibrosis (RPF) exhibiting various clinical manifestations. Our current understanding of immunoglobulin G4 (IgG4)-related disease led us to consider it as a possible diagnosis because all of the patient's clinical features could be explained by this...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421133/ https://www.ncbi.nlm.nih.gov/pubmed/30333398 http://dx.doi.org/10.2169/internalmedicine.1241-18 |
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author | Konno, Satoshi Matsuno, Yoshihiro Ichimiya, Shingo Nishimura, Masaharu Kawakami, Yoshikazu |
author_facet | Konno, Satoshi Matsuno, Yoshihiro Ichimiya, Shingo Nishimura, Masaharu Kawakami, Yoshikazu |
author_sort | Konno, Satoshi |
collection | PubMed |
description | In 1982, we reported a case of retroperitoneal fibrosis (RPF) exhibiting various clinical manifestations. Our current understanding of immunoglobulin G4 (IgG4)-related disease led us to consider it as a possible diagnosis because all of the patient's clinical features could be explained by this disease entity. To confirm our hypothesis, were investigated the histopathological findings of resected specimens that had been stored for 35 years postoperatively. Typical pathological findings together with predominant IgG4(+) plasma cell infiltration confirmed a potential diagnosis of IgG4-related RPF. Furthermore, we observed positive immunohistochemical staining for several molecules associated with T regulatory and T follicular helper cells. |
format | Online Article Text |
id | pubmed-6421133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-64211332019-03-18 Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years Konno, Satoshi Matsuno, Yoshihiro Ichimiya, Shingo Nishimura, Masaharu Kawakami, Yoshikazu Intern Med Case Report In 1982, we reported a case of retroperitoneal fibrosis (RPF) exhibiting various clinical manifestations. Our current understanding of immunoglobulin G4 (IgG4)-related disease led us to consider it as a possible diagnosis because all of the patient's clinical features could be explained by this disease entity. To confirm our hypothesis, were investigated the histopathological findings of resected specimens that had been stored for 35 years postoperatively. Typical pathological findings together with predominant IgG4(+) plasma cell infiltration confirmed a potential diagnosis of IgG4-related RPF. Furthermore, we observed positive immunohistochemical staining for several molecules associated with T regulatory and T follicular helper cells. The Japanese Society of Internal Medicine 2018-10-17 2019-02-15 /pmc/articles/PMC6421133/ /pubmed/30333398 http://dx.doi.org/10.2169/internalmedicine.1241-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Konno, Satoshi Matsuno, Yoshihiro Ichimiya, Shingo Nishimura, Masaharu Kawakami, Yoshikazu Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years |
title | Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years |
title_full | Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years |
title_fullStr | Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years |
title_full_unstemmed | Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years |
title_short | Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years |
title_sort | retroperitoneal fibrosis diagnosed as igg4-related disease after 35 years |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421133/ https://www.ncbi.nlm.nih.gov/pubmed/30333398 http://dx.doi.org/10.2169/internalmedicine.1241-18 |
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