Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept

Chronic active Epstein-Barr virus (CAEBV) T-cell type infection, systemic form, is characterized by persistent infectious mononucleosis-like symptoms, high Epstein-Barr virus (EBV) DNA levels in the peripheral blood, organ damage, and a poor prognosis. The association between CAEBV and rheumatoid ar...

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Autores principales: Kawabe, Akio, Nakano, Kazuhisa, Miyata, Hiroko, Shibuya, Ryo, Matsuyama, Atsuji, Ogoshi, Takaaki, Tanaka, Yoshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421150/
https://www.ncbi.nlm.nih.gov/pubmed/30210119
http://dx.doi.org/10.2169/internalmedicine.1280-18
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author Kawabe, Akio
Nakano, Kazuhisa
Miyata, Hiroko
Shibuya, Ryo
Matsuyama, Atsuji
Ogoshi, Takaaki
Tanaka, Yoshiya
author_facet Kawabe, Akio
Nakano, Kazuhisa
Miyata, Hiroko
Shibuya, Ryo
Matsuyama, Atsuji
Ogoshi, Takaaki
Tanaka, Yoshiya
author_sort Kawabe, Akio
collection PubMed
description Chronic active Epstein-Barr virus (CAEBV) T-cell type infection, systemic form, is characterized by persistent infectious mononucleosis-like symptoms, high Epstein-Barr virus (EBV) DNA levels in the peripheral blood, organ damage, and a poor prognosis. The association between CAEBV and rheumatoid arthritis (RA) is unclear. We report a case of fatal CAEBV T-cell type infection in an RA patient undergoing treatment with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin fusion protein (abatacept, ABT). CAEBV can rapidly worsen in RA patients receiving ABT. Thus, we should try to establish an early diagnosis in patients with CAEBV infection.
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spelling pubmed-64211502019-03-18 Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept Kawabe, Akio Nakano, Kazuhisa Miyata, Hiroko Shibuya, Ryo Matsuyama, Atsuji Ogoshi, Takaaki Tanaka, Yoshiya Intern Med Case Report Chronic active Epstein-Barr virus (CAEBV) T-cell type infection, systemic form, is characterized by persistent infectious mononucleosis-like symptoms, high Epstein-Barr virus (EBV) DNA levels in the peripheral blood, organ damage, and a poor prognosis. The association between CAEBV and rheumatoid arthritis (RA) is unclear. We report a case of fatal CAEBV T-cell type infection in an RA patient undergoing treatment with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin fusion protein (abatacept, ABT). CAEBV can rapidly worsen in RA patients receiving ABT. Thus, we should try to establish an early diagnosis in patients with CAEBV infection. The Japanese Society of Internal Medicine 2018-09-12 2019-02-15 /pmc/articles/PMC6421150/ /pubmed/30210119 http://dx.doi.org/10.2169/internalmedicine.1280-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kawabe, Akio
Nakano, Kazuhisa
Miyata, Hiroko
Shibuya, Ryo
Matsuyama, Atsuji
Ogoshi, Takaaki
Tanaka, Yoshiya
Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept
title Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept
title_full Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept
title_fullStr Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept
title_full_unstemmed Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept
title_short Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept
title_sort fatal chronic active epstein-barr virus infection in a rheumatoid arthritis patient treated with abatacept
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421150/
https://www.ncbi.nlm.nih.gov/pubmed/30210119
http://dx.doi.org/10.2169/internalmedicine.1280-18
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