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Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis

This review addresses nuclear SPECT and PET imaging in small animals in relation to the atherosclerotic disease process, one of our research topics of interest. Imaging of atherosclerosis in small animal models is challenging, as it operates at the limits of current imaging possibilities regarding s...

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Autores principales: Meester, Eric J., Krenning, B. J., de Swart, J., Segbers, M., Barrett, H. E., Bernsen, M. R., Van der Heiden, K., de Jong, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421263/
https://www.ncbi.nlm.nih.gov/pubmed/30915335
http://dx.doi.org/10.3389/fmed.2019.00039
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author Meester, Eric J.
Krenning, B. J.
de Swart, J.
Segbers, M.
Barrett, H. E.
Bernsen, M. R.
Van der Heiden, K.
de Jong, Marion
author_facet Meester, Eric J.
Krenning, B. J.
de Swart, J.
Segbers, M.
Barrett, H. E.
Bernsen, M. R.
Van der Heiden, K.
de Jong, Marion
author_sort Meester, Eric J.
collection PubMed
description This review addresses nuclear SPECT and PET imaging in small animals in relation to the atherosclerotic disease process, one of our research topics of interest. Imaging of atherosclerosis in small animal models is challenging, as it operates at the limits of current imaging possibilities regarding sensitivity, and spatial resolution. Several topics are discussed, including technical considerations that apply to image acquisition, reconstruction, and analysis. Moreover, molecules developed for or applied in these small animal nuclear imaging studies are listed, including target-directed molecules, useful for imaging organs or tissues that have elevated expression of the target compared to other tissues, and molecules that serve as substrates for metabolic processes. Differences between animal models and human pathophysiology that should be taken into account during translation from animal to patient as well as differences in tracer behavior in animal vs. man are also described. Finally, we give a future outlook on small animal radionuclide imaging in atherosclerosis, followed by recommendations. The challenges and solutions described might be applicable to other research fields of health and disease as well.
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spelling pubmed-64212632019-03-26 Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis Meester, Eric J. Krenning, B. J. de Swart, J. Segbers, M. Barrett, H. E. Bernsen, M. R. Van der Heiden, K. de Jong, Marion Front Med (Lausanne) Medicine This review addresses nuclear SPECT and PET imaging in small animals in relation to the atherosclerotic disease process, one of our research topics of interest. Imaging of atherosclerosis in small animal models is challenging, as it operates at the limits of current imaging possibilities regarding sensitivity, and spatial resolution. Several topics are discussed, including technical considerations that apply to image acquisition, reconstruction, and analysis. Moreover, molecules developed for or applied in these small animal nuclear imaging studies are listed, including target-directed molecules, useful for imaging organs or tissues that have elevated expression of the target compared to other tissues, and molecules that serve as substrates for metabolic processes. Differences between animal models and human pathophysiology that should be taken into account during translation from animal to patient as well as differences in tracer behavior in animal vs. man are also described. Finally, we give a future outlook on small animal radionuclide imaging in atherosclerosis, followed by recommendations. The challenges and solutions described might be applicable to other research fields of health and disease as well. Frontiers Media S.A. 2019-03-11 /pmc/articles/PMC6421263/ /pubmed/30915335 http://dx.doi.org/10.3389/fmed.2019.00039 Text en Copyright © 2019 Meester, Krenning, de Swart, Segbers, Barrett, Bernsen, Van der Heiden and de Jong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Meester, Eric J.
Krenning, B. J.
de Swart, J.
Segbers, M.
Barrett, H. E.
Bernsen, M. R.
Van der Heiden, K.
de Jong, Marion
Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis
title Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis
title_full Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis
title_fullStr Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis
title_full_unstemmed Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis
title_short Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis
title_sort perspectives on small animal radionuclide imaging; considerations and advances in atherosclerosis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421263/
https://www.ncbi.nlm.nih.gov/pubmed/30915335
http://dx.doi.org/10.3389/fmed.2019.00039
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