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Rare Dihydropyrimidine Dehydrogenase Variants and Toxicity by Floropyrimidines: A Case Report

Variations in the activity, up to absolute deficiency, of the enzyme dihydropyrimidine dehydrogenase (DPD), result in the occurrence of adverse reactions to chemotherapy, and have been included among the pharmacogenetic factors underlying inter-individual variability in response to fluoropyrimidines...

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Detalles Bibliográficos
Autores principales:	Palmirotta, Raffaele, Lovero, Domenica, Delacour, Hervé, Le Roy, Audrey, Cremades, Serge, Silvestris, Franco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421267/ https://www.ncbi.nlm.nih.gov/pubmed/30915274 http://dx.doi.org/10.3389/fonc.2019.00139

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