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Combined pulmonary fibrosis and emphysema characteristics in a Greek cohort

BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) has recently received great attention, with studies suggesting that it presents a distinct clinical entity while others have challenged this hypothesis. This nationwide study aimed to describe a large cohort of Greek CPFE patients and to e...

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Detalles Bibliográficos
Autores principales: Malli, Foteini, Papakosta, Despoina, Antoniou, Katerina, Dimadi, Maria, Polychronopoulos, Vlassis, Malagari, Katerina, Oikonomou, Anastasia, Bouros, Demosthenes E., Daniil, Zoe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421361/
https://www.ncbi.nlm.nih.gov/pubmed/30895186
http://dx.doi.org/10.1183/23120541.00014-2018
Descripción
Sumario:BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) has recently received great attention, with studies suggesting that it presents a distinct clinical entity while others have challenged this hypothesis. This nationwide study aimed to describe a large cohort of Greek CPFE patients and to examine potential prognostic factors for survival. METHODS: This retrospective study included 97 patients with CPFE. Demographic and clinical data, pulmonary function tests, echocardiography results and bronchoalveolar lavage analysis were recorded. RESULTS: Most patients were male (94.8%) and 92% were current or ex-smokers. Spirometry results were abnormal (forced vital capacity (FVC) 72.9±19.9% pred and forced expiratory volume in 1 s/FVC 82.9±9.7%) with reduced diffusing capacity of the lung for carbon monoxide (D(LCO)) (42.3±17.4% pred). Mean systolic pulmonary arterial pressure was 41.9±19.7 mmHg and pulmonary hypertension was present in 58.8% of patients. Mean 6-min walk distance was 335.4±159.4 m. Mean emphysema score was 14.23±8.69% and mean interstitial lung disease (ILD) extent was 39.58±19.82%. Mean survival was 84 months (95% CI 72–96 months). Patients with D(LCO) ≥39% pred had better survival than patients with D(LCO) <39% pred (p=0.031). Patients with ILD extent ≥30% had worse survival than patients with ILD extent <30% (p=0.037). CONCLUSIONS: Our results indicate that CPFE patients have preserved lung volumes associated with disproportionately reduced D(LCO), while reduced D(LCO) and increased ILD extent was associated with worse prognosis.