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Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
OBJECTIVE: Intestinal permeability increases during the course of acute pancreatitis (AP). We assessed duodenal permeability alterations in patients with AP by confocal laser endomicroscopy (CLE). METHODS: Thirty patients with AP underwent CLE evaluation of the antral and duodenal mucosa. Images wer...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421367/ https://www.ncbi.nlm.nih.gov/pubmed/32516018 http://dx.doi.org/10.1177/0300060518820430 |
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author | Sun, Lingjia Yue, Min Dai, Yining Yu, Chaohui Chen, Chunxiao |
author_facet | Sun, Lingjia Yue, Min Dai, Yining Yu, Chaohui Chen, Chunxiao |
author_sort | Sun, Lingjia |
collection | PubMed |
description | OBJECTIVE: Intestinal permeability increases during the course of acute pancreatitis (AP). We assessed duodenal permeability alterations in patients with AP by confocal laser endomicroscopy (CLE). METHODS: Thirty patients with AP underwent CLE evaluation of the antral and duodenal mucosa. Images were graded based on the appearance of capillaries and the degree of fluorescein leakage. RESULTS: Patients with AP had increased duodenal mucosal permeability that could be detected by CLE. The mucosal permeability progressively increased in the gastric antrum, duodenal bulb, and descending duodenum. The CLE parameters in the antrum and duodenal bulb were not significantly different between patients with mild and severe AP. The CLE grades in the descending duodenum were higher in patients with severe than mild AP. The C-reactive protein level in AP was positively correlated with the permeability in the duodenal bulb and descending duodenum, while the computed tomography severity index score was positively correlated with the mucosal permeability in the duodenal bulb and descending duodenum. CONCLUSION: CLE revealed increased duodenal permeability in patients with AP. Higher permeability in the descending duodenum was observed in severe than mild AP. Further large-scale studies are needed to confirm the relationship between altered duodenal permeability and the severity of AP. |
format | Online Article Text |
id | pubmed-6421367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-64213672019-03-22 Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis Sun, Lingjia Yue, Min Dai, Yining Yu, Chaohui Chen, Chunxiao J Int Med Res Pre-Clinical Research Reports OBJECTIVE: Intestinal permeability increases during the course of acute pancreatitis (AP). We assessed duodenal permeability alterations in patients with AP by confocal laser endomicroscopy (CLE). METHODS: Thirty patients with AP underwent CLE evaluation of the antral and duodenal mucosa. Images were graded based on the appearance of capillaries and the degree of fluorescein leakage. RESULTS: Patients with AP had increased duodenal mucosal permeability that could be detected by CLE. The mucosal permeability progressively increased in the gastric antrum, duodenal bulb, and descending duodenum. The CLE parameters in the antrum and duodenal bulb were not significantly different between patients with mild and severe AP. The CLE grades in the descending duodenum were higher in patients with severe than mild AP. The C-reactive protein level in AP was positively correlated with the permeability in the duodenal bulb and descending duodenum, while the computed tomography severity index score was positively correlated with the mucosal permeability in the duodenal bulb and descending duodenum. CONCLUSION: CLE revealed increased duodenal permeability in patients with AP. Higher permeability in the descending duodenum was observed in severe than mild AP. Further large-scale studies are needed to confirm the relationship between altered duodenal permeability and the severity of AP. SAGE Publications 2019-03-09 2019-03 /pmc/articles/PMC6421367/ /pubmed/32516018 http://dx.doi.org/10.1177/0300060518820430 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Pre-Clinical Research Reports Sun, Lingjia Yue, Min Dai, Yining Yu, Chaohui Chen, Chunxiao Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis |
title | Confocal laser endomicroscopy reveals alterations in duodenal
permeability in patients with acute pancreatitis |
title_full | Confocal laser endomicroscopy reveals alterations in duodenal
permeability in patients with acute pancreatitis |
title_fullStr | Confocal laser endomicroscopy reveals alterations in duodenal
permeability in patients with acute pancreatitis |
title_full_unstemmed | Confocal laser endomicroscopy reveals alterations in duodenal
permeability in patients with acute pancreatitis |
title_short | Confocal laser endomicroscopy reveals alterations in duodenal
permeability in patients with acute pancreatitis |
title_sort | confocal laser endomicroscopy reveals alterations in duodenal
permeability in patients with acute pancreatitis |
topic | Pre-Clinical Research Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421367/ https://www.ncbi.nlm.nih.gov/pubmed/32516018 http://dx.doi.org/10.1177/0300060518820430 |
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