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Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis

OBJECTIVE: Intestinal permeability increases during the course of acute pancreatitis (AP). We assessed duodenal permeability alterations in patients with AP by confocal laser endomicroscopy (CLE). METHODS: Thirty patients with AP underwent CLE evaluation of the antral and duodenal mucosa. Images wer...

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Autores principales: Sun, Lingjia, Yue, Min, Dai, Yining, Yu, Chaohui, Chen, Chunxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421367/
https://www.ncbi.nlm.nih.gov/pubmed/32516018
http://dx.doi.org/10.1177/0300060518820430
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author Sun, Lingjia
Yue, Min
Dai, Yining
Yu, Chaohui
Chen, Chunxiao
author_facet Sun, Lingjia
Yue, Min
Dai, Yining
Yu, Chaohui
Chen, Chunxiao
author_sort Sun, Lingjia
collection PubMed
description OBJECTIVE: Intestinal permeability increases during the course of acute pancreatitis (AP). We assessed duodenal permeability alterations in patients with AP by confocal laser endomicroscopy (CLE). METHODS: Thirty patients with AP underwent CLE evaluation of the antral and duodenal mucosa. Images were graded based on the appearance of capillaries and the degree of fluorescein leakage. RESULTS: Patients with AP had increased duodenal mucosal permeability that could be detected by CLE. The mucosal permeability progressively increased in the gastric antrum, duodenal bulb, and descending duodenum. The CLE parameters in the antrum and duodenal bulb were not significantly different between patients with mild and severe AP. The CLE grades in the descending duodenum were higher in patients with severe than mild AP. The C-reactive protein level in AP was positively correlated with the permeability in the duodenal bulb and descending duodenum, while the computed tomography severity index score was positively correlated with the mucosal permeability in the duodenal bulb and descending duodenum. CONCLUSION: CLE revealed increased duodenal permeability in patients with AP. Higher permeability in the descending duodenum was observed in severe than mild AP. Further large-scale studies are needed to confirm the relationship between altered duodenal permeability and the severity of AP.
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spelling pubmed-64213672019-03-22 Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis Sun, Lingjia Yue, Min Dai, Yining Yu, Chaohui Chen, Chunxiao J Int Med Res Pre-Clinical Research Reports OBJECTIVE: Intestinal permeability increases during the course of acute pancreatitis (AP). We assessed duodenal permeability alterations in patients with AP by confocal laser endomicroscopy (CLE). METHODS: Thirty patients with AP underwent CLE evaluation of the antral and duodenal mucosa. Images were graded based on the appearance of capillaries and the degree of fluorescein leakage. RESULTS: Patients with AP had increased duodenal mucosal permeability that could be detected by CLE. The mucosal permeability progressively increased in the gastric antrum, duodenal bulb, and descending duodenum. The CLE parameters in the antrum and duodenal bulb were not significantly different between patients with mild and severe AP. The CLE grades in the descending duodenum were higher in patients with severe than mild AP. The C-reactive protein level in AP was positively correlated with the permeability in the duodenal bulb and descending duodenum, while the computed tomography severity index score was positively correlated with the mucosal permeability in the duodenal bulb and descending duodenum. CONCLUSION: CLE revealed increased duodenal permeability in patients with AP. Higher permeability in the descending duodenum was observed in severe than mild AP. Further large-scale studies are needed to confirm the relationship between altered duodenal permeability and the severity of AP. SAGE Publications 2019-03-09 2019-03 /pmc/articles/PMC6421367/ /pubmed/32516018 http://dx.doi.org/10.1177/0300060518820430 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Pre-Clinical Research Reports
Sun, Lingjia
Yue, Min
Dai, Yining
Yu, Chaohui
Chen, Chunxiao
Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
title Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
title_full Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
title_fullStr Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
title_full_unstemmed Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
title_short Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
title_sort confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
topic Pre-Clinical Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421367/
https://www.ncbi.nlm.nih.gov/pubmed/32516018
http://dx.doi.org/10.1177/0300060518820430
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