Cargando…

Inhibition of protease-activated receptor-2 induces apoptosis in cervical cancer by inhibiting signal transducer and activator of transcription-3 signaling

OBJECTIVE: The present study explored how the inhibition of protease-activated receptor-2 (PAR-2) induced proliferation and apoptosis in cervical cancer in vitro and in vivo. METHODS: mRNA and protein expression of PAR2 and signal transducer and activator of transcription-3 (STAT-3) was determined b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shanshan, Hu, Lan, Xiao, Xia, Li, Huang, Wang, Meifang, Zuo, Ling, Yin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2019
Materias:	Pre-Clinical Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421370/ https://www.ncbi.nlm.nih.gov/pubmed/30700181 http://dx.doi.org/10.1177/0300060518820440

Ejemplares similares

WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway
por: Xia, Yonghua, et al.
Publicado: (2018)

Correlation of signal transducer and activator of transcription-3 and β-catenin expression in laryngeal squamous cell carcinoma
por: Sun, Yajing, et al.
Publicado: (2023)

The role of Src homology region 2 domain-containing phosphatase-1 hypermethylation in the classification of patients with myelodysplastic syndromes and its association with signal transducer and activator of transcription 3 phosphorylation in skm-1 cells
por: Han, Ying, et al.
Publicado: (2021)

Protective action of the ginsenoside Rh3 in a rat myocardial ischemia-reperfusion injury model by inhibition of apoptosis induced via p38 mitogen-activated protein kinase/caspase-3 signaling
por: Cao, Liexiang, et al.
Publicado: (2020)

Activation of autophagy during farnesyl pyrophosphate synthase inhibition is mediated through PI3K/AKT/mTOR signaling
por: Han, Jie, et al.
Publicado: (2019)

Miconazole inhibits signal transducer and activator of transcription 3 signaling by preventing its interaction with DNA damage‐induced apoptosis suppressor
por: Yoon, Sung‐Hoon, et al.
Publicado: (2020)

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma
por: de Groot, John, et al.
Publicado: (2012)

Dexmedetomidine attenuates cerebral ischemia/reperfusion injury in neonatal rats by inhibiting TLR4 signaling
por: Cheng, Jiangxia, et al.
Publicado: (2018)

Activation-Induced Inhibition of Interleukin 6–Mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling
por: Teague, T. Kent, et al.
Publicado: (2000)

Nelfinavir restricts A549 cell growth by inhibiting STAT3 signaling
por: He, Fangli, et al.
Publicado: (2021)

Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells
por: Siveen, K S, et al.
Publicado: (2014)

Paris polyphylla 26 triggers G2/M phase arrest and induces apoptosis in HepG2 cells via inhibition of the Akt signaling pathway
por: Li, Qiang, et al.
Publicado: (2019)

Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development
por: Bromberg, Jacqueline
Publicado: (2000)

AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1
por: He, Chaoyong, et al.
Publicado: (2015)

Antitumor activity of Raddeanin A is mediated by Jun amino‐terminal kinase activation and signal transducer and activator of transcription 3 inhibition in human osteosarcoma
por: Wang, Zhuoying, et al.
Publicado: (2019)

Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation
por: Jamasbi, Janina, et al.
Publicado: (2016)

Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway
por: Wu, Shibo, et al.
Publicado: (2020)

Inhibition of Interleukin 2 Signaling and Signal Transducer and Activator of Transcription (Stat)5 Activation during T Cell Receptor–Mediated Feedback Inhibition of T Cell Expansion
por: Lee, In-Hong, et al.
Publicado: (1999)

Ginkgetin inhibits the growth of DU−145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
por: Jeon, Yoon Jung, et al.
Publicado: (2015)

Baicalin Inhibits Human Cervical Cancer Cells by Suppressing Protein Kinase C/Signal Transducer and Activator of Transcription (PKC/STAT3) Signaling Pathway
por: Wang, Qianqian, et al.
Publicado: (2018)

Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells
por: Li, Xiaofei, et al.
Publicado: (2020)

Lnc-NEAT1 induces cell apoptosis and inflammation but inhibits proliferation in a cellular model of hepatic ischemia/reperfusion injury
por: Wang, Liu, et al.
Publicado: (2021)

Fingolimod attenuates renal ischemia/reperfusion-induced acute lung injury by inhibiting inflammation and apoptosis and modulating S1P metabolism
por: Shi, Zu-an, et al.
Publicado: (2021)

Laricitrin ameliorates lung cancer-mediated dendritic cell suppression by inhibiting signal transducer and activator of transcription 3
por: Chang, Wei-An, et al.
Publicado: (2016)

2′‐Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation
por: Yoon, Yae Jin, et al.
Publicado: (2018)

MicroRNA-22-3p alleviates atherosclerosis by mediating macrophage M2 polarization as well as inhibiting NLRP3 activation
por: Bian, Xiaoyan, et al.
Publicado: (2023)

MLN4924 inhibits cell proliferation by targeting the activated neddylation pathway in endometrial carcinoma
por: Liu, Huanrong, et al.
Publicado: (2021)

Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer
por: Venkatasubbarao, Kolaparthi, et al.
Publicado: (2013)

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies
por: Arora, Loukik, et al.
Publicado: (2018)

GLP-1 alleviates NLRP3 inflammasome-dependent inflammation in perivascular adipose tissue by inhibiting the NF-κB signalling pathway
por: Chen, Xiangheng, et al.
Publicado: (2021)

Tumor necrosis factor-related apoptosis-inducing ligand modulates angiogenesis and apoptosis to inhibit non-small cell lung carcinoma tumor growth in mice
por: Chen, Yuanmei, et al.
Publicado: (2019)

Bilateral Superior Cervical Sympathectomy Activates Signal Transducer and Activator of Transcription 3 Signal to Alleviate Myocardial Ischemia-Reperfusion Injury
por: Li, Lixia, et al.
Publicado: (2022)

Signal Transducer and Activator of Transcription 4 in Liver Diseases
por: Wang, Yan, et al.
Publicado: (2015)

The Rho kinase signaling pathway participates in tubular mitochondrial oxidative injury and apoptosis in uric acid nephropathy
por: Su, Yan, et al.
Publicado: (2021)

Histone methyltransferase Dot1L inhibits pancreatic cancer cell apoptosis by promoting NUPR1 expression
por: Shan, Lin, et al.
Publicado: (2022)

Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling
por: FUJIWARA, YUKIO, et al.
Publicado: (2013)

MicroRNA-519a inhibits the proliferation and promotes the apoptosis of ovarian cancer cells through targeting signal transducer and activator of transcription 3
por: Tian, Fei, et al.
Publicado: (2018)

Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis
por: Wang, Guangxin, et al.
Publicado: (2023)

Lipoxin A4 promotes autophagy and inhibits overactivation of macrophage inflammasome activity induced by Pg LPS
por: Zhao, Jie, et al.
Publicado: (2021)

Atractylenolide I alleviates ischemia/reperfusion injury by preserving mitochondrial function and inhibiting caspase-3 activity
por: Sun, Caiqin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ljn6agrgv8mdvp6ad4fvvkehj8