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Activation of GCN2 by the ribosomal P-stalk

Cells dynamically adjust their protein translation profile to maintain homeostasis in changing environments. During nutrient stress, the kinase general control nonderepressible 2 (GCN2) phosphorylates translation initiation factor eIF2α, initiating the integrated stress response (ISR). To examine th...

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Detalles Bibliográficos
Autores principales:	Inglis, Alison J., Masson, Glenn R., Shao, Sichen, Perisic, Olga, McLaughlin, Stephen H., Hegde, Ramanujan S., Williams, Roger L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421407/ https://www.ncbi.nlm.nih.gov/pubmed/30804176 http://dx.doi.org/10.1073/pnas.1813352116

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