Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

[Image: see text] A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found to be potent anti-Wolbachia antibiotics and, as such, may be useful in the treatment of filarial infections caused by Onchoc...

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Detalles Bibliográficos
Autores principales: Jacobs, Robert T., Lunde, Christopher S., Freund, Yvonne R., Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S., Berry, Pamela W., Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J., Ford, Louise, Johnston, Kelly L., Cook, Darren A. N., Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F., Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J., Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P., McNamara, Case W., Bakowski, Malina A., Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421521/
https://www.ncbi.nlm.nih.gov/pubmed/30730745
http://dx.doi.org/10.1021/acs.jmedchem.8b01854

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